Literature DB >> 11994739

How cells change their phenotype.

David Tosh1, Jonathan M W Slack.   

Abstract

Recent attention has focused on the remarkable ability of adult stem cells to produce differentiated cells from embryologically unrelated tissues. This phenomenon is an example of metaplasia and shows that embryological commitments can be reversed or erased under certain circumstances. In some cases, even fully differentiated cells can change their phenotype (transdifferentiation). This review examines recently discovered cases of metaplasia, and speculates on the potential molecular and cellular mechanisms that underlie the switches, and their significance to developmental biology and medicine.

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Year:  2002        PMID： 11994739     DOI： 10.1038/nrm761

Source DB:  PubMed          Journal:  Nat Rev Mol Cell Biol        ISSN： 1471-0072            Impact factor:   94.444


  107 in total

1.  Activation of the BMP4 pathway and early expression of CDX2 characterize non-specialized columnar metaplasia in a human model of Barrett's esophagus.

Authors:  Daniel Castillo; Sonia Puig; Mar Iglesias; Agustín Seoane; Carme de Bolós; Vicente Munitiz; Pascual Parrilla; Laura Comerma; Richard Poulsom; Kausilia K Krishnadath; Luís Grande; Manuel Pera
Journal:  J Gastrointest Surg       Date:  2011-11-11       Impact factor: 3.452

Review 2.  Recipes for adult stem cell plasticity: fusion cuisine or readymade?

Authors:  M R Alison; R Poulsom; W R Otto; P Vig; M Brittan; N C Direkze; M Lovell; T C Fang; S L Preston; N A Wright
Journal:  J Clin Pathol       Date:  2004-02       Impact factor: 3.411

3.  Localized chemical release from an artificial synapse chip.

Authors:  Mark C Peterman; Jaan Noolandi; Mark S Blumenkranz; Harvey A Fishman
Journal:  Proc Natl Acad Sci U S A       Date:  2004-06-24       Impact factor: 11.205

Review 4.  Generation of surrogate beta cells from tissue stem cells.

Authors:  Shimon Efrat
Journal:  Curr Diab Rep       Date:  2004-08       Impact factor: 4.810

Review 5.  The role of acid and bile reflux in oesophagitis and Barrett's metaplasia.

Authors:  Rhonda F Souza
Journal:  Biochem Soc Trans       Date:  2010-04       Impact factor: 5.407

6.  Created equal? The many facets of cell reprogramming.

Authors:  Annarosa Leri; Jan Kajstura
Journal:  Circ Res       Date:  2012-07-06       Impact factor: 17.367

Review 7.  Barrett's Esophagus: A Comprehensive and Contemporary Review for Pathologists.

Authors:  Bita V Naini; Rhonda F Souza; Robert D Odze
Journal:  Am J Surg Pathol       Date:  2016-05       Impact factor: 6.394

8.  Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation.

Authors:  Takeshi Miyatsuka; Hideaki Kaneto; Toshihiko Shiraiwa; Taka-aki Matsuoka; Kaoru Yamamoto; Ken Kato; Yumiko Nakamura; Shizuo Akira; Kiyoshi Takeda; Yoshitaka Kajimoto; Yoshimitsu Yamasaki; Eric P Sandgren; Yoshiya Kawaguchi; Christopher V E Wright; Yoshio Fujitani
Journal:  Genes Dev       Date:  2006-06-01       Impact factor: 11.361

9.  Stem cell therapy to treat diabetes mellitus.

Authors:  Chee Gee Liew; Peter W Andrews
Journal:  Rev Diabet Stud       Date:  2009-02-10

10.  Hepatocyte nuclear factor-4alpha induces transdifferentiation of hematopoietic cells into hepatocytes.

Authors:  Satish Khurana; Amit K Jaiswal; Asok Mukhopadhyay
Journal:  J Biol Chem       Date:  2009-12-16       Impact factor: 5.157
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