| Literature DB >> 29206279 |
K A Metcalfe1,2, J Lubinski3, J Gronwald3, T Huzarski3, J McCuaig4, H T Lynch5, B Karlan6, W D Foulkes7, C F Singer8, S L Neuhausen9, L Senter10, A Eisen11, P Sun2, S A Narod10.
Abstract
The objective of this study was to estimate the lifetime risk of breast cancer in women with a BRCA1 or BRCA2 mutation with and without at least 1 first-degree relative with breast cancer. A total of 2835 women with a BRCA1 or BRCA2 mutation were followed. Age- and gene-specific breast cancer rates were calculated. The relative risks of breast cancer for subjects with a family history of breast cancer, compared to no family history were calculated. The mean age at baseline was 41.1 years, and they were followed for a mean of 6.0 years. The estimated penetrance of breast cancer to age 80 years was 60.8% for BRCA1 and 63.1% for BRCA2. For all BRCA carriers, the penetrance of breast cancer to age 80 for those with no first-degree relative with breast cancer was 60.4% and 63.3% for those with at least 1 first-degree relative with breast cancer. The risk of breast cancer for BRCA carriers with no first-degree relative with breast cancer is substantial, and as a result, clinical management for these women should be the same as those for women with an affected relative.Entities:
Keywords: BRCA1; BRCA2; breast cancer; family history
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Year: 2018 PMID： 29206279 DOI： 10.1111/cge.13191
Source DB: PubMed Journal: Clin Genet ISSN： 0009-9163 Impact factor: 4.438