| Literature DB >> 29198436 |
Martina Schmittnaegel1, Michele De Palma2.
Abstract
Angiogenic blood vessels contribute to generating an immunosuppressive tumor microenvironment, in part by limiting the extravasation of T cells. Functional reprogramming of angiogenic blood vessels, for example through angiopoietin-2 blockade, may improve T cell trafficking in tumors and the efficacy of immune checkpoint blockade (ICB) and other cancer immunotherapies.Entities:
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Year: 2017 PMID: 29198436 DOI: 10.1016/j.trecan.2017.10.002
Source DB: PubMed Journal: Trends Cancer ISSN: 2405-8025