Lisa M Wu1,2, Ali Amidi3, Heiddis Valdimarsdottir1,4, Sonia Ancoli-Israel5,6, Lianqi Liu5, Gary Winkel1, Emily E Byrne1, Ana Vallejo Sefair7, Alejandro Vega1, Katrin Bovbjerg2, William H Redd1. 1. Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York. 2. Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois. 3. Unit for Psychooncology and Health Psychology, Department of Oncology, Aarhus University Hospital, Aarhus, Denmark. 4. Department of Psychology, Reykjavik University, Reykjavik, Iceland. 5. Department of Psychiatry, University of California, San Diego, California. 6. Department of Medicine, University of California, San Diego, California. 7. Department of Clinical and Social Psychology, University of Rochester, Rochester, New York.
Abstract
STUDY OBJECTIVES:Sleep disturbances are commonly reported by cancer survivors. Systematic light exposure using bright light has been used to improve sleep in other populations. In this secondary data analysis, the effect of morning administration of bright light on sleep and sleep quality was examined in a mixed group of fatigued cancer survivors. METHODS:Forty-four cancer survivors screened for cancer-related fatigue were randomized to either a bright white light or a comparison dim red light condition. Participants were instructed to use a light box every morning for 30 minutes for 4 weeks. Wrist actigraphy and the Pittsburgh Sleep Quality Index were administered at 4 time points: prior to light treatment (baseline), 2 weeks into the intervention, during the last week of the intervention, and 3 weeks postintervention. Thirty-seven participants completed the end-of-intervention assessment. RESULTS: Repeated-measures linear mixed models indicated a statistically significant time × treatment group interaction effect with sleep efficiency improving more in the bright light condition over time compared with the dim light condition (F3,42 = 5.55; P = .003) with a large effect size (partial η2 = 0.28). By the end of the intervention and 3 weeks postintervention, mean sleep efficiency in the bright light group was in the normal range. Medium to large effect sizes were also seen in sleep quality, total sleep time, and wake after sleep onset for participants favoring the bright light condition. CONCLUSIONS: The results suggest that systematic bright light exposure in the morning may have beneficial effects on sleep in fatigued cancer survivors. Larger scale efficacy trials are warranted. CLINICAL TRIAL REGISTRATION: Registry: ClinicalTrials.gov, Title: Treating Cancer-Related Fatigue Through Systematic Light Exposure, Identifier: NCT01873794, URL: https://clinicaltrials.gov/ct2/show/NCT01873794.
RCT Entities:
STUDY OBJECTIVES: Sleep disturbances are commonly reported by cancer survivors. Systematic light exposure using bright light has been used to improve sleep in other populations. In this secondary data analysis, the effect of morning administration of bright light on sleep and sleep quality was examined in a mixed group of fatigued cancer survivors. METHODS: Forty-four cancer survivors screened for cancer-related fatigue were randomized to either a bright white light or a comparison dim red light condition. Participants were instructed to use a light box every morning for 30 minutes for 4 weeks. Wrist actigraphy and the Pittsburgh Sleep Quality Index were administered at 4 time points: prior to light treatment (baseline), 2 weeks into the intervention, during the last week of the intervention, and 3 weeks postintervention. Thirty-seven participants completed the end-of-intervention assessment. RESULTS: Repeated-measures linear mixed models indicated a statistically significant time × treatment group interaction effect with sleep efficiency improving more in the bright light condition over time compared with the dim light condition (F3,42 = 5.55; P = .003) with a large effect size (partial η2 = 0.28). By the end of the intervention and 3 weeks postintervention, mean sleep efficiency in the bright light group was in the normal range. Medium to large effect sizes were also seen in sleep quality, total sleep time, and wake after sleep onset for participants favoring the bright light condition. CONCLUSIONS: The results suggest that systematic bright light exposure in the morning may have beneficial effects on sleep in fatigued cancer survivors. Larger scale efficacy trials are warranted. CLINICAL TRIAL REGISTRATION: Registry: ClinicalTrials.gov, Title: Treating Cancer-Related Fatigue Through Systematic Light Exposure, Identifier: NCT01873794, URL: https://clinicaltrials.gov/ct2/show/NCT01873794.
Authors: Sonia Ancoli-Israel; Michelle Rissling; Ariel Neikrug; Vera Trofimenko; Loki Natarajan; Barbara A Parker; Susan Lawton; Paul Desan; Lianqi Liu Journal: Support Care Cancer Date: 2011-06-11 Impact factor: 3.603
Authors: William H Redd; Heiddis Valdimarsdottir; Lisa M Wu; Gary Winkel; Emily E Byrne; Melba A Beltre; Elizabeth S Liebman; Tanya Erazo; Judy A Hayes; Luis Isola; Eileen Scigliano; Yeraz Meschian; Susan Lutgendorf; Sonia Ancoli-Israel Journal: Psychooncology Date: 2014-05-02 Impact factor: 3.894
Authors: Sonia Ancoli-Israel; Lianqi Liu; Michelle Rissling; Loki Natarajan; Ariel B Neikrug; Barton W Palmer; Paul J Mills; Barbara A Parker; Georgia Robins Sadler; Jeanne Maglione Journal: Support Care Cancer Date: 2014-04-15 Impact factor: 3.603
Authors: AnnaLynn M Williams; Carly Paterson Khan; Charles E Heckler; Debra L Barton; Mary Ontko; Jodi Geer; Amber S Kleckner; Shaker Dakhil; Jerry Mitchell; Karen M Mustian; Luke J Peppone; Victor Kipnis; Charles S Kamen; Ann M O'Mara; Michelle C Janelsins Journal: Breast Cancer Res Treat Date: 2021-01-04 Impact factor: 4.872
Authors: Heiðdís B Valdimarsdottir; Mariana G Figueiro; William Holden; Susan Lutgendorf; Lisa M Wu; Sonia Ancoli-Israel; Jason Chen; Ariella Hoffman-Peterson; Julia Granski; Nina Prescott; Alejandro Vega; Natalie Stern; Gary Winkel; William H Redd Journal: Cancer Med Date: 2018-08-11 Impact factor: 4.452
Authors: Daniëlle E J Starreveld; Laurien A Daniels; Heiddis B Valdimarsdottir; William H Redd; Jessie L de Geus; Sonia Ancoli-Israel; Susan Lutgendorf; Catharina M Korse; Jacobien M Kieffer; Flora E van Leeuwen; Eveline M A Bleiker Journal: BMC Cancer Date: 2018-09-10 Impact factor: 4.430
Authors: Helena R Bean; Lesley Stafford; Ruth Little; Justine Diggens; Maria Ftanou; Marliese Alexander; Prudence A Francis; Bei Bei; Joshua F Wiley Journal: Trials Date: 2020-03-27 Impact factor: 2.279