| Literature DB >> 29195908 |
Cuiying Liu1, Jian Yang1, Chencheng Zhang1, Menglei Liu1, Xiaokun Geng2, Xunming Ji3, Huishan Du4, Heng Zhao5.
Abstract
Long noncoding RNAs (lncRNAs) have a variety of biological functions and play key roles in many diseases. However, the knowledge of lncRNA function during a stroke is limited. We analyzed the expression profiles of lncRNAs in the brain ischemic region of mice after a 45min middle cerebral artery occlusion (MCAO) with a 48h reperfusion. Gene ontology and pathway analysis were used to elucidate the potential functions of the differentially expressed mRNAs. A total of 255 lncRNAs (217 up-regulated and 38 down-regulated) and 894 mRNAs (870 up-regulated and 24 down-regulated) showed significantly altered expression in the ischemic brain compared to the sham controls (fold change ≫>2, P≪0.05). The gene ontology terms were mainly associated with neutrophil chemotaxis, positive regulation of inflammatory response, cell cycle, positive regulation of apoptotic process, and apoptotic process. The pathway analysis indicated that the mRNAs were mainly associated with inflammatory pathways. Additionally, the interactions between the differentially expressed lncRNAs and mRNAs are revealed by a dynamic lncRNA-mRNA network. Our findings provide an overview of aberrantly expressed lncRNAs in stroke and further broaden the understanding of stroke pathogenesis.Entities:
Keywords: Bioinformatics; Ischemia/reperfusion; Long noncoding RNA; Stroke; mRNAs
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Year: 2017 PMID： 29195908 PMCID： PMC5955004 DOI： 10.1016/j.neulet.2017.11.058
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046