Tatsuya Maruhashi1, Junko Soga1, Noritaka Fujimura1, Naomi Idei1, Shinsuke Mikami1, Yumiko Iwamoto1, Akimichi Iwamoto1, Masato Kajikawa1, Takeshi Matsumoto1, Nozomu Oda1, Shinji Kishimoto1, Shogo Matsui1, Haruki Hashimoto1, Yoshiki Aibara2, Farina Mohamad Yusoff2, Takayuki Hidaka1, Yasuki Kihara1, Kazuaki Chayama3, Kensuke Noma4, Ayumu Nakashima5, Chikara Goto6, Hirofumi Tomiyama7, Bonpei Takase8, Takahide Kohro7, Toru Suzuki9, Tomoko Ishizu10, Shinichiro Ueda11, Tsutomu Yamazaki12, Tomoo Furumoto13, Kazuomi Kario14, Teruo Inoue15, Shinji Koba16, Kentaro Watanabe17, Yasuhiko Takemoto18, Takuzo Hano19, Masataka Sata20, Yutaka Ishibashi21, Koichi Node22, Koji Maemura23, Yusuke Ohya24, Taiji Furukawa25, Hiroshi Ito26, Hisao Ikeda27, Akira Yamashina7, Yukihito Higashi28. 1. Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan. 2. Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan. 3. Department of Gastroenterology and Metabolism, Biomedical Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan. 4. Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan; Division of Regeneration and Medicine, Hiroshima University Hospital, Hiroshima, Japan. 5. Division of Regeneration and Medicine, Hiroshima University Hospital, Hiroshima, Japan. 6. Hiroshima International University, Hiroshima, Japan. 7. Department of Cardiology, Tokyo Medical University, Tokyo, Japan. 8. Division of Biomedical Engineering, National Defense Medical College Research Institute, Tokorozawa, Japan. 9. Cardiovascular Medicine, University of Leicester, Leicester, UK. 10. Cardiovascular Division, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan. 11. Department of Clinical Pharmacology and Therapeutics, University of the Ryukyu School of Medicine, Okinawa, Japan. 12. Clinical Research Support Center, Faculty of Medicine, The University of Tokyo, Tokyo, Japan. 13. Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Hokkaido, Japan. 14. Division of Cardiovascular Medicine, Jichi Medical University School of Medicine, Tochigi, Japan. 15. Department of Cardiovascular Medicine, Dokkyo Medical University, Mibu, Tochigi, Japan. 16. Department of Medicine, Division of Cardiology, Showa University School of Medicine, Tokyo, Japan. 17. Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology (DNHMED), Yamagata University School of Medicine, Yamagata, Japan. 18. Department of Internal Medicine and Cardiology, Osaka City University Graduate School of Medicine, Osaka, Japan. 19. Department of Medical Education and Population-based Medicine, Postgraduate School of Medicine, Wakayama Medical University, Wakayama, Japan. 20. Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. 21. Department of General Medicine, Shimane University Faculty of Medicine, Izumo, Japan. 22. Department of Cardiovascular and Renal Medicine, Saga University, Saga, Japan. 23. Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. 24. The Third Department of Internal Medicine, University of the Ryukyus, Okinawa, Japan. 25. Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan. 26. Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan. 27. Faculty of Fukuoka Medical Technology, Teikyo University, Omuta, Japan. 28. Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan; Division of Regeneration and Medicine, Hiroshima University Hospital, Hiroshima, Japan. Electronic address: yhigashi@hiroshima-u.ac.jp.
Abstract
BACKGROUND AND AIMS: Baseline brachial artery (BBA) diameter has been reported to be a potential confounding factor of flow-mediated vasodilation (FMD). The purpose of this study was to evaluate the relationships between BBA diameter and cardiovascular risk factors and compare the diagnostic accuracy of BBA diameter in subjects without cardiovascular risk factors and patients with cardiovascular disease (CVD) with that of FMD. METHODS: We measured BBA diameter and FMD in 5695 male subjects. In addition, we retrospectively investigated the incidence of cardiovascular events using another population sample consisting of 440 male subjects, to compare the accuracy of BBA diameter with that of FMD in predicting cardiovascular events. RESULTS: BBA diameter and FMD significantly correlated with age, body mass index, systolic blood pressure, diastolic blood pressure, triglycerides, high-density lipoprotein cholesterol, and glucose as well as Framingham risk score. The prevalence of cardiovascular risk factors and CVD increased with the increase in BBA diameter and FMD. Area under the curve (AUC) value of the receiver operating characteristic (ROC) curve for BBA diameter to diagnose subjects without cardiovascular risk factors (0.59 vs. 0.62, p = 0.001) or patients with CVD (0.58 vs. 0.64, p < 0.001) was significantly lower than that for FMD. In the retrospective study, the AUC value of the ROC curve for BBA diameter to predict first major cardiovascular events was significantly lower than that of FMD (0.50 vs. 0.62, p = 0.03). CONCLUSIONS: In men, BBA diameter was inferior to FMD for assessment of cardiovascular risk.
BACKGROUND AND AIMS: Baseline brachial artery (BBA) diameter has been reported to be a potential confounding factor of flow-mediated vasodilation (FMD). The purpose of this study was to evaluate the relationships between BBA diameter and cardiovascular risk factors and compare the diagnostic accuracy of BBA diameter in subjects without cardiovascular risk factors and patients with cardiovascular disease (CVD) with that of FMD. METHODS: We measured BBA diameter and FMD in 5695 male subjects. In addition, we retrospectively investigated the incidence of cardiovascular events using another population sample consisting of 440 male subjects, to compare the accuracy of BBA diameter with that of FMD in predicting cardiovascular events. RESULTS:BBA diameter and FMD significantly correlated with age, body mass index, systolic blood pressure, diastolic blood pressure, triglycerides, high-density lipoprotein cholesterol, and glucose as well as Framingham risk score. The prevalence of cardiovascular risk factors and CVD increased with the increase in BBA diameter and FMD. Area under the curve (AUC) value of the receiver operating characteristic (ROC) curve for BBA diameter to diagnose subjects without cardiovascular risk factors (0.59 vs. 0.62, p = 0.001) or patients with CVD (0.58 vs. 0.64, p < 0.001) was significantly lower than that for FMD. In the retrospective study, the AUC value of the ROC curve for BBA diameter to predict first major cardiovascular events was significantly lower than that of FMD (0.50 vs. 0.62, p = 0.03). CONCLUSIONS: In men, BBA diameter was inferior to FMD for assessment of cardiovascular risk.
Authors: Saurabh S Thosar; Daniel Chess; Nicole P Bowles; Andrew W McHill; Matthew P Butler; Jonathan S Emens; Steven A Shea Journal: Nat Sci Sleep Date: 2021-09-22
Authors: Yong Zhang; Ya-Jun Zhang; Hong-Wei Zhang; Wei-Bing Ye; Mallikarjuna Korivi Journal: Int J Environ Res Public Health Date: 2021-06-22 Impact factor: 3.390