Literature DB >> 29189834

In trans hydrolysis of carrier protein-bound acyl intermediates by CitA during citrinin biosynthesis.

Philip A Storm1, Craig A Townsend.   

Abstract

Polyketide synthases (PKSs) have several known editing mechanisms to ensure that non-productive intermediates are removed from the acyl carrier protein (ACP). We demonstrate that CitA, a putative hydrolase in the citrinin biosynthetic gene cluster, removes ACP-bound acyl intermediates. We propose that it serves an editing role in trans.

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Year:  2017        PMID： 29189834      PMCID： PMC5822715          DOI： 10.1039/c7cc07079a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  24 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  2016-02-01       Impact factor: 11.205

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Authors:  Joel Bruegger; Robert W Haushalter; Bob Haushalter; Anna L Vagstad; Anna Vagstad; Gaurav Shakya; Nathan Mih; Craig A Townsend; Michael D Burkart; Shiou-Chuan Tsai
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5.  Polyketide synthase gene responsible for citrinin biosynthesis in Monascus purpureus.

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8.  Lysine acetylation is a highly abundant and evolutionarily conserved modification in Escherichia coli.

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9.  Acyl hydrolases from trans-AT polyketide synthases target acetyl units on acyl carrier proteins.

Authors:  Matthew Jenner; Jose P Afonso; Christoph Kohlhaas; Petra Karbaum; Sarah Frank; Jörn Piel; Neil J Oldham
Journal:  Chem Commun (Camb)       Date:  2016-03-22       Impact factor: 6.222

10.  Systematic domain swaps of iterative, nonreducing polyketide synthases provide a mechanistic understanding and rationale for catalytic reprogramming.

Authors:  Adam G Newman; Anna L Vagstad; Philip A Storm; Craig A Townsend
Journal:  J Am Chem Soc       Date:  2014-05-09       Impact factor: 15.419
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  3 in total

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2.  A proof-reading mechanism for non-proteinogenic amino acid incorporation into glycopeptide antibiotics.

Authors:  Milda Kaniusaite; Julien Tailhades; Edward A Marschall; Robert J A Goode; Ralf B Schittenhelm; Max J Cryle
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Review 3.  Core Steps to the Azaphilone Family of Fungal Natural Products.

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Journal:  Chembiochem       Date:  2021-07-09       Impact factor: 3.164
  3 in total

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