Literature DB >> 29188356

[Antihypertensive therapy in the elderly].

J Schrader1, B Schrader2.   

Abstract

Arterial hypertension is the most common modifiable risk factor for cerebrovascular and cardiovascular morbidity and mortality in old age. The prevention of cognitive brain disorders is also a therapeutic goal of long-term treatment of hypertension. Older patients also have a higher risk of developing cardiovascular diseases and therefore benefit from a relatively moderate reduction in blood pressure. With respect to the high prevalence of hypertension in old age and the increasing incidence with time, the therapy of hypertension is becoming increasingly more important to achieve an improved prognosis for patients along with a reduction of costs. The accurate blood pressure measurement for elderly patients includes repeated measurements while standing and sitting. Additionally, the measurements should also be conducted by the patient or by a family member. The most accurate method for assessing the daily blood pressure level, e.g. practice hypertension, non-dipping and intermittent hypertension, is the 24-h blood pressure measurement by ambulatory blood pressure monitoring (ABPM). General measures and lifestyle interventions are effective for reducing blood pressure of elderly patients with hypertension and a low salt diet is scientifically proven to be superior. The same drugs used for young people are also recommended for older patients and most give preference to diuretics, renin-angiotensin-aldosterone system (RAAS) inhibitors and calcium antagonists. The target blood pressure in elderly patients is repeatedly the focus of scientific discussions. The current recommendations are presented in the text and the characteristics which must be particularly considered in the therapy of elderly patients are presented in detail.

Entities:  

Keywords:  Aged; Blood pressure lowering; Cognitive impairment; Hypertension; Target blood pressure

Mesh:

Substances:

Year:  2018        PMID: 29188356     DOI: 10.1007/s00059-017-4642-6

Source DB:  PubMed          Journal:  Herz        ISSN: 0340-9937            Impact factor:   1.443


  51 in total

Review 1.  Association of a difference in systolic blood pressure between arms with vascular disease and mortality: a systematic review and meta-analysis.

Authors:  Christopher E Clark; Rod S Taylor; Angela C Shore; Obioha C Ukoumunne; John L Campbell
Journal:  Lancet       Date:  2012-01-30       Impact factor: 79.321

2.  Essential hypertension in the elderly: haemodynamics, intravascular volume, plasma renin activity, and circulating catecholamine levels.

Authors:  F H Messerli; K Sundgaard-Riise; H O Ventura; F G Dunn; L B Glade; E D Frohlich
Journal:  Lancet       Date:  1983-10-29       Impact factor: 79.321

3.  Treatment With Multiple Blood Pressure Medications, Achieved Blood Pressure, and Mortality in Older Nursing Home Residents: The PARTAGE Study.

Authors:  Athanase Benetos; Carlos Labat; Patrick Rossignol; Renaud Fay; Yves Rolland; Filippo Valbusa; Paolo Salvi; Mauro Zamboni; Patrick Manckoundia; Olivier Hanon; Sylvie Gautier
Journal:  JAMA Intern Med       Date:  2015-06       Impact factor: 21.873

Review 4.  2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.

Authors:  Paul K Whelton; Robert M Carey; Wilbert S Aronow; Donald E Casey; Karen J Collins; Cheryl Dennison Himmelfarb; Sondra M DePalma; Samuel Gidding; Kenneth A Jamerson; Daniel W Jones; Eric J MacLaughlin; Paul Muntner; Bruce Ovbiagele; Sidney C Smith; Crystal C Spencer; Randall S Stafford; Sandra J Taler; Randal J Thomas; Kim A Williams; Jeff D Williamson; Jackson T Wright
Journal:  J Am Coll Cardiol       Date:  2017-11-13       Impact factor: 24.094

5.  The Cardiovascular Risk of White-Coat Hypertension.

Authors:  Stanley S Franklin; Lutgarde Thijs; Kei Asayama; Yan Li; Tine W Hansen; José Boggia; Lotte Jacobs; Zhenyu Zhang; Masahiro Kikuya; Kristina Björklund-Bodegård; Takayoshi Ohkubo; Wen-Yi Yang; Jørgen Jeppesen; Eamon Dolan; Tatiana Kuznetsova; Katarzyna Stolarz-Skrzypek; Valérie Tikhonoff; Sofia Malyutina; Edoardo Casiglia; Yuri Nikitin; Lars Lind; Edgardo Sandoya; Kalina Kawecka-Jaszcz; Jan Filipovský; Yutaka Imai; Ji-Guang Wang; Eoin O'Brien; Jan A Staessen
Journal:  J Am Coll Cardiol       Date:  2016-11-08       Impact factor: 24.094

6.  Health-related quality of life of subjects with known and unknown hypertension: results from the population-based Hortega study.

Authors:  Francisco J Mena-Martin; Juan C Martin-Escudero; Fernando Simal-Blanco; Jose L Carretero-Ares; Delfin Arzua-Mouronte; Vicente Herreros-Fernandez
Journal:  J Hypertens       Date:  2003-07       Impact factor: 4.844

Review 7.  Pulse pressure, arterial stiffness and wave reflections (augmentation index) as cardiovascular risk factors in hypertension.

Authors:  Michel E Safar
Journal:  Ther Adv Cardiovasc Dis       Date:  2008-02

8.  No evidence that frailty modifies the positive impact of antihypertensive treatment in very elderly people: an investigation of the impact of frailty upon treatment effect in the HYpertension in the Very Elderly Trial (HYVET) study, a double-blind, placebo-controlled study of antihypertensives in people with hypertension aged 80 and over.

Authors:  Jane Warwick; Emanuela Falaschetti; Kenneth Rockwood; Arnold Mitnitski; Lutgarde Thijs; Nigel Beckett; Christopher Bulpitt; Ruth Peters
Journal:  BMC Med       Date:  2015-04-09       Impact factor: 8.775

9.  Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants.

Authors: 
Journal:  Lancet       Date:  2016-11-16       Impact factor: 79.321

10.  2013 ESH/ESC guidelines for the management of arterial hypertension: the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC).

Authors:  Giuseppe Mancia; Robert Fagard; Krzysztof Narkiewicz; Josep Redon; Alberto Zanchetti; Michael Böhm; Thierry Christiaens; Renata Cifkova; Guy De Backer; Anna Dominiczak; Maurizio Galderisi; Diederick E Grobbee; Tiny Jaarsma; Paulus Kirchhof; Sverre E Kjeldsen; Stéphane Laurent; Athanasios J Manolis; Peter M Nilsson; Luis Miguel Ruilope; Roland E Schmieder; Per Anton Sirnes; Peter Sleight; Margus Viigimaa; Bernard Waeber; Faiez Zannad; Josep Redon; Anna Dominiczak; Krzysztof Narkiewicz; Peter M Nilsson; Michel Burnier; Margus Viigimaa; Ettore Ambrosioni; Mark Caufield; Antonio Coca; Michael Hecht Olsen; Roland E Schmieder; Costas Tsioufis; Philippe van de Borne; Jose Luis Zamorano; Stephan Achenbach; Helmut Baumgartner; Jeroen J Bax; Héctor Bueno; Veronica Dean; Christi Deaton; Cetin Erol; Robert Fagard; Roberto Ferrari; David Hasdai; Arno W Hoes; Paulus Kirchhof; Juhani Knuuti; Philippe Kolh; Patrizio Lancellotti; Ales Linhart; Petros Nihoyannopoulos; Massimo F Piepoli; Piotr Ponikowski; Per Anton Sirnes; Juan Luis Tamargo; Michal Tendera; Adam Torbicki; William Wijns; Stephan Windecker; Denis L Clement; Antonio Coca; Thierry C Gillebert; Michal Tendera; Enrico Agabiti Rosei; Ettore Ambrosioni; Stefan D Anker; Johann Bauersachs; Jana Brguljan Hitij; Mark Caulfield; Marc De Buyzere; Sabina De Geest; Geneviève Anne Derumeaux; Serap Erdine; Csaba Farsang; Christian Funck-Brentano; Vjekoslav Gerc; Giuseppe Germano; Stephan Gielen; Herman Haller; Arno W Hoes; Jens Jordan; Thomas Kahan; Michel Komajda; Dragan Lovic; Heiko Mahrholdt; Michael Hecht Olsen; Jan Ostergren; Gianfranco Parati; Joep Perk; Jorge Polonia; Bogdan A Popescu; Zeljko Reiner; Lars Rydén; Yuriy Sirenko; Alice Stanton; Harry Struijker-Boudier; Costas Tsioufis; Philippe van de Borne; Charalambos Vlachopoulos; Massimo Volpe; David A Wood
Journal:  Eur Heart J       Date:  2013-06-14       Impact factor: 29.983

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