Fatemeh Seifar1, Mohammad Khalili1,2, Habib Khaledyan3, Shirin Amiri Moghadam4, Azimeh Izadi5, Amirreza Azimi2, Seied Kazem Shakouri6. 1. a Neurosciences Research Center, Tabriz University of Medical Sciences , Tabriz , Iran. 2. e Multiple Sclerosis Research Center , Tehran , Iran. 3. b Physical Medicine and Rehabilitation Research Center, Tabriz University of Medical Sciences , Tabriz , Iran. 4. c Faculty of Medicine, Department of Community Medicine , Hormozgan University of Medical Sciences , Bandar Abbas , Iran. 5. d Faculty of Nutrition and Food Science, Department of Biochemistry and Diet Therapy , Nutrition Research Center, Tabriz University of Medical Sciences , Tabriz , Iran. 6. f Physical Medicine and Rehabilitation Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.
Abstract
OBJECTIVES: α-lipoic acid (ALA) is a natural antioxidant which acts as a cofactor of bioenergetic mitochondrial enzymes. Along with its mitochondrial action, ALA and its reduced form have many biological functions resulting in a wide variety of actions such as anti-inflammation and antioxidant protection, scavenging reactive oxygen species, regenerating other antioxidant agents, such as vitamins C and E, and cytosolic glutathione, chelating the transitional metal ions (e.g. iron and copper), and modulating the signal transduction of nuclear factor. METHODS: By selecting papers from PubMed, Science Direct, EBSCO, and databases, this review discusses the biochemical properties of LA, its mechanism of action, pharmacokinetics, and its possible therapeutic role in central nervous system diseases, such as Alzheimer's disease, Parkinson's disease, Multiple sclerosis, stroke, and spinal cord injury. RESULTS: ALA as an antioxidant and anti-inflammation agent has therapeutical effects on central nervous system diseases, especially multiple sclerosis and PD. DISCUSSION: ALA can be considered as a potentially useful treatment in central nervous disorders.
OBJECTIVES: α-lipoic acid (ALA) is a natural antioxidant which acts as a cofactor of bioenergetic mitochondrial enzymes. Along with its mitochondrial action, ALA and its reduced form have many biological functions resulting in a wide variety of actions such as anti-inflammation and antioxidant protection, scavenging reactive oxygen species, regenerating other antioxidant agents, such as vitamins C and E, and cytosolic glutathione, chelating the transitional metal ions (e.g. iron and copper), and modulating the signal transduction of nuclear factor. METHODS: By selecting papers from PubMed, Science Direct, EBSCO, and databases, this review discusses the biochemical properties of LA, its mechanism of action, pharmacokinetics, and its possible therapeutic role in central nervous system diseases, such as Alzheimer's disease, Parkinson's disease, Multiple sclerosis, stroke, and spinal cord injury. RESULTS:ALA as an antioxidant and anti-inflammation agent has therapeutical effects on central nervous system diseases, especially multiple sclerosis and PD. DISCUSSION: ALA can be considered as a potentially useful treatment in central nervous disorders.
Authors: Dolores T Ramírez-Lamelas; Soledad Benlloch-Navarro; Rosa López-Pedrajas; Roberto Gimeno-Hernández; Teresa Olivar; Dolores Silvestre; María Miranda Journal: Front Pharmacol Date: 2018-05-09 Impact factor: 5.810