Epidemiological studies on micronutrient consumption have reported protective associations in the incidence and/or progression of various cancer types. Supplementation with some of these micronutrients has been analyzed, showing chemoprotection, low toxicity, antiproliferation, and the ability to modify epigenetic signatures in various cancer models. This review investigates the reported effects of micronutrient intake or supplementation in breast cancer progression. A PubMed search was conducted with the keywords "micronutrients breast cancer progression", and the results were analyzed. The selected micronutrients were vitamins (C, D, and E), folic acid, metals (Cu, Fe, Se, and Zn), fatty acids, polyphenols, and iodine. The majority of in vitro models showed antiproliferative, cell-cycle arrest, and antimetastatic effects for almost all the micronutrients analyzed, but these effects do not reflect animal or human studies. Only one clinical trial with vitamin D and one pilot study with molecular iodine showed favorable overall survival and disease-free interval.
Epidemiological studies on micronutrient consumption have reported protective associations in the incidence and/or progression of various cancer types. Supplepan class="Species">mentation with some of these micronutrients has been analyzed, showing chemoprotection, low toxicity, antiproliferation, and the ability to modify epigenetic signatures in various cancer models. This review investigates the reported effects of micronutrient intake or supplementation in breast cancer progression. A PubMed search was conducted with the keywords "micronutrients breast cancer progression", and the results were analyzed. The selected micronutrients were vitamins (C, D, and E), folic acid, metals (Cu, Fe, Se, and Zn), fatty acids, polyphenols, and iodine. The majority of in vitro models showed antiproliferative, cell-cycle arrest, and antimetastatic effects for almost all the micronutrients analyzed, but these effects do not reflect animal or human studies. Only one clinical trial with vitamin D and one pilot study with molecular iodine showed favorable overall survival and disease-free interval.
Authors: Srilatha Swami; Aruna V Krishnan; Jasmaine Williams; Abhishek Aggarwal; Megan A Albertelli; Ronald L Horst; Brian J Feldman; David Feldman Journal: Endocr Relat Cancer Date: 2016-01-27 Impact factor: 5.678
Authors: David Feldman; Aruna V Krishnan; Srilatha Swami; Edward Giovannucci; Brian J Feldman Journal: Nat Rev Cancer Date: 2014-04-04 Impact factor: 60.716
Authors: Olga Cuenca-Micó; Evangelina Delgado-González; Brenda Anguiano; Felipe Vaca-Paniagua; Alejandra Medina-Rivera; Mauricio Rodríguez-Dorantes; Carmen Aceves Journal: Biomolecules Date: 2021-10-12