| Literature DB >> 29185167 |
Kaori Maeyama1, Kazumi Tomioka1, Hiroaki Nagase1, Mieko Yoshioka2, Yasuko Takagi2, Takeshi Kato3, Masami Mizobuchi4, Shinji Kitayama5, Satoshi Takada6, Masashi Nagai1, Nana Sakakibara1, Masahiro Nishiyama1, Mariko Taniguchi-Ikeda1, Ichiro Morioka1, Kazumoto Iijima1, Noriyuki Nishimura7.
Abstract
Association of congenital cytomegalovirus (CMV) infection with autism spectral disorder (ASD) has been suggested since 1980s. Despite the observed association, its role as a risk factor for ASD remains to be defined. In the present review, we systematically evaluated the available evidence associating congenital CMV infection with ASD using PubMed, Web of Science, Cochrane Library, and Embase databases. Any studies on children with CMV infection and ASD were evaluated for eligibility and three observational studies were included in meta-analysis. Although a high prevalence of congenital CMV infection in ASD cases (OR 11.31, 95% CI 3.07-41.66) was indicated, too few events (0-2 events) in all included studies imposed serious limitations. There is urgent need for further studies to clarify this issue.Entities:
Keywords: ASD; Congenital CMV infection; Maternal immune activation; Neurodevelopmental disorder; Prenatal environment; Risk factor
Mesh：
Year: 2018 PMID： 29185167 DOI： 10.1007/s10803-017-3412-x
Source DB: PubMed Journal: J Autism Dev Disord ISSN： 0162-3257