Srijit Banerjee1, Kate Manley1, Barnabas Shaw2, Liane Lewis3, Gabriel Cucato4, Robert Mills1, Mark Rochester1, Allan Clark5, John M Saxton6. 1. Department of Urology, Norfolk and Norwich University Hospital, Colney Lane, Norwich, NR4 7UY, UK. 2. School of Health Sciences, Faculty of Medicine and Health Sciences, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK. 3. Department of Computer and Information Sciences, University of Strathclyde, Glasgow, G1 1XH, UK. 4. School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil. 5. Norwich Medical School, Faculty of Medicine and Health Sciences, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK. 6. Department of Sport, Exercise and Rehabilitation, Faculty of Health and Life Sciences, Northumbria University, Room NB259 Northumberland Building, Newcastle upon Tyne, NE1 8ST, UK. john.saxton@northumbria.ac.uk.
Abstract
PURPOSE: Strategies to improve pre-operative cardiopulmonary fitness could positively impact recovery after surgery. This study investigated the feasibility of vigorous intensity aerobic interval exercise in bladder cancer patients prior to radical cystectomy (RC). METHODS: A total of 60 patients were randomised (1:1) to exercise or control following a cardiopulmonary exercise test (CPET). The exercise group was offered twice-weekly pre-operative supervised vigorous intensity aerobic interval exercise in addition to standard treatment. The controls received standard treatment only. A repeat CPET was undertaken before surgery and post-operative recovery outcomes were recorded. RESULTS: Over half of the 112 eligible patients approached in the clinic were recruited to the study (53.5%), with recruited patients attending a median of 8 (range 1-10) exercise sessions over a pre-operative period of 3-6 weeks. Improvements in peak values of oxygen pulse (P = 0.001), minute ventilation (P = 0.002) and power output (P < 0.001) were observed at the follow-up CPET in the exercise group versus controls and there were no adverse events. Although this feasibility study was not powered to detect changes in post-operative recovery outcomes, there were marginal (non-significant) differences in favour of the exercise group in post-operative Clavien-Dindo score and need for high dependency unit inotropic support. CONCLUSIONS:Bladder cancer patients respond well to pre-surgical aerobic interval exercise, and the improvements in cardiopulmonary fitness variables could have important implications for post-operative recuperation after RC. These findings provide a strong foundation for an adequately powered randomised controlled trial.
RCT Entities:
PURPOSE: Strategies to improve pre-operative cardiopulmonary fitness could positively impact recovery after surgery. This study investigated the feasibility of vigorous intensity aerobic interval exercise in bladder cancerpatients prior to radical cystectomy (RC). METHODS: A total of 60 patients were randomised (1:1) to exercise or control following a cardiopulmonary exercise test (CPET). The exercise group was offered twice-weekly pre-operative supervised vigorous intensity aerobic interval exercise in addition to standard treatment. The controls received standard treatment only. A repeat CPET was undertaken before surgery and post-operative recovery outcomes were recorded. RESULTS: Over half of the 112 eligible patients approached in the clinic were recruited to the study (53.5%), with recruited patients attending a median of 8 (range 1-10) exercise sessions over a pre-operative period of 3-6 weeks. Improvements in peak values of oxygen pulse (P = 0.001), minute ventilation (P = 0.002) and power output (P < 0.001) were observed at the follow-up CPET in the exercise group versus controls and there were no adverse events. Although this feasibility study was not powered to detect changes in post-operative recovery outcomes, there were marginal (non-significant) differences in favour of the exercise group in post-operative Clavien-Dindo score and need for high dependency unit inotropic support. CONCLUSIONS:Bladder cancerpatients respond well to pre-surgical aerobic interval exercise, and the improvements in cardiopulmonary fitness variables could have important implications for post-operative recuperation after RC. These findings provide a strong foundation for an adequately powered randomised controlled trial.
Authors: D Santa Mina; H Clarke; P Ritvo; Y W Leung; A G Matthew; J Katz; J Trachtenberg; S M H Alibhai Journal: Physiotherapy Date: 2013-11-13 Impact factor: 3.358
Authors: Lee W Jones; Carolyn J Peddle; Neil D Eves; Mark J Haykowsky; Kerry S Courneya; John R Mackey; Anil A Joy; Vikaash Kumar; Timothy W Winton; Tony Reiman Journal: Cancer Date: 2007-08-01 Impact factor: 6.860
Authors: Chelsia Gillis; Chao Li; Lawrence Lee; Rashami Awasthi; Berson Augustin; Ann Gamsa; A Sender Liberman; Barry Stein; Patrick Charlebois; Liane S Feldman; Francesco Carli Journal: Anesthesiology Date: 2014-11 Impact factor: 7.892
Authors: Malcolm A West; Lisa Loughney; Daniel Lythgoe; Christopher P Barben; Valerie L Adams; William E Bimson; Michael P W Grocott; Sandy Jack; Graham J Kemp Journal: PLoS One Date: 2014-12-05 Impact factor: 3.240
Authors: Elliott Freudenburg; Iyla Bagheri; Sunay Srinivas; Ariza Martinez; Nagireddy Putluri; Zachary Klaassen; Ashish M Kamat; Badrinath R Konety; William Y Kim; Lars Dyrskjøt; David J McConkey; Stephen J Freedland; Peter C Black; Siamak Daneshmand; James W F Catto; Stephen B Williams Journal: Cancer Causes Control Date: 2022-06-14 Impact factor: 2.532
Authors: Jessica M Scott; Emily C Zabor; Emily Schwitzer; Graeme J Koelwyn; Scott C Adams; Tormod S Nilsen; Chaya S Moskowitz; Konstantina Matsoukas; Neil M Iyengar; Chau T Dang; Lee W Jones Journal: J Clin Oncol Date: 2018-06-12 Impact factor: 44.544
Authors: Jamie L Waterland; Orla McCourt; Lara Edbrooke; Catherine L Granger; Hilmy Ismail; Bernhard Riedel; Linda Denehy Journal: Front Surg Date: 2021-03-19
Authors: Catherine F S Marriott; Andrea F M Petrella; Emily C S Marriott; Narlon C Boa Sorte Silva; Robert J Petrella Journal: Sports Med Open Date: 2021-07-19
Authors: Stefano Palma; Timothy Hasenoehrl; Galateja Jordakieva; Dariga Ramazanova; Richard Crevenna Journal: Support Care Cancer Date: 2020-10-26 Impact factor: 3.603