Literature DB >> 29177185

A Murine Orthotopic Allograft to Model Prostate Cancer Growth and Metastasis.

Robert M Hughes1,2,3, Brian W Simons1, Paula J Hurley1,2,3.   

Abstract

Prostate cancer is one of the most common cancers in men in the United States. Comprehensive understanding of the biology contributing to prostate cancer will have important clinical implications. Animal models have greatly impacted our knowledge of disease and will continue to be a valuable resource for future studies. Herein, we describe a detailed protocol for the orthotopic engraftment of a murine prostate cancer cell line (Myc-CaP) into the anterior prostate of an immune competent mouse.

Entities:  

Keywords:  Cancer; Metastasis; Mouse model; Myc-CaP; Orthotopic allograft; Prostate; in vivo

Year:  2017        PMID： 29177185      PMCID： PMC5701568          DOI： 10.21769/BioProtoc.2137

Source DB:  PubMed          Journal:  Bio Protoc        ISSN： 2331-8325


  20 in total

1.  Guidelines for the design and statistical analysis of experiments using laboratory animals.

Authors:  Michael F W Festing; Douglas G Altman
Journal:  ILAR J       Date:  2002

2.  Necropsy and sampling procedures in rodents.

Authors:  Laurence Fiette; Mohamed Slaoui
Journal:  Methods Mol Biol       Date:  2011

3.  Pre-clinical mouse models of human prostate cancer and their utility in drug discovery.

Authors:  Serk In Park; Sun Jin Kim; Laurie K McCauley; Gary E Gallick
Journal:  Curr Protoc Pharmacol       Date:  2010-12

4.  A human prostatic bacterial isolate alters the prostatic microenvironment and accelerates prostate cancer progression.

Authors:  Brian W Simons; Nicholas M Durham; Tullia C Bruno; Joseph F Grosso; Anthony J Schaeffer; Ashley E Ross; Paula J Hurley; David M Berman; Charles G Drake; Praveen Thumbikat; Edward M Schaeffer
Journal:  J Pathol       Date:  2015-02       Impact factor: 7.996

5.  Local regulation of human breast xenograft models.

Authors:  Jodie M Fleming; Tyler C Miller; Matthew J Meyer; Erika Ginsburg; Barbara K Vonderhaar
Journal:  J Cell Physiol       Date:  2010-09       Impact factor: 6.384

6.  Context-dependent hormone-refractory progression revealed through characterization of a novel murine prostate cancer cell line.

Authors:  Philip A Watson; Katharine Ellwood-Yen; Jennifer C King; John Wongvipat; Michelle M Lebeau; Charles L Sawyers
Journal:  Cancer Res       Date:  2005-12-15       Impact factor: 12.701

7.  Animal models of human prostate cancer: the consensus report of the New York meeting of the Mouse Models of Human Cancers Consortium Prostate Pathology Committee.

Authors:  Michael Ittmann; Jiaoti Huang; Enrico Radaelli; Philip Martin; Sabina Signoretti; Ruth Sullivan; Brian W Simons; Jerrold M Ward; Brian D Robinson; Gerald C Chu; Massimo Loda; George Thomas; Alexander Borowsky; Robert D Cardiff
Journal:  Cancer Res       Date:  2013-04-22       Impact factor: 12.701

8.  Prostate cancer in a transgenic mouse.

Authors:  N M Greenberg; F DeMayo; M J Finegold; D Medina; W D Tilley; J O Aspinall; G R Cunha; A A Donjacour; R J Matusik; J M Rosen
Journal:  Proc Natl Acad Sci U S A       Date:  1995-04-11       Impact factor: 11.205

9.  Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer.

Authors:  Shunyou Wang; Jing Gao; Qunying Lei; Nora Rozengurt; Colin Pritchard; Jing Jiao; George V Thomas; Gang Li; Pradip Roy-Burman; Peter S Nelson; Xin Liu; Hong Wu
Journal:  Cancer Cell       Date:  2003-09       Impact factor: 31.743

10.  Myc-driven murine prostate cancer shares molecular features with human prostate tumors.

Authors:  Katharine Ellwood-Yen; Thomas G Graeber; John Wongvipat; M Luisa Iruela-Arispe; JianFeng Zhang; Robert Matusik; George V Thomas; Charles L Sawyers
Journal:  Cancer Cell       Date:  2003-09       Impact factor: 31.743
View more
  3 in total

1.  Asporin Restricts Mesenchymal Stromal Cell Differentiation, Alters the Tumor Microenvironment, and Drives Metastatic Progression.

Authors:  Robert M Hughes; Brian W Simons; Hamda Khan; Rebecca Miller; Valentina Kugler; Samantha Torquato; Debebe Theodros; Michael C Haffner; Tamara Lotan; Jessie Huang; Elai Davicioni; Steven S An; Ryan C Riddle; Daniel L J Thorek; Isla P Garraway; Elana J Fertig; John T Isaacs; W Nathaniel Brennen; Ben H Park; Paula J Hurley
Journal:  Cancer Res       Date:  2019-05-23       Impact factor: 12.701

2.  Modeling Human Prostate Cancer Metastasis in Mice via Resection of Subcutaneous Allografts.

Authors:  Lauren B Peiffer; Jessica Hicks; Rebecca Y Sosa; Angelo M De Marzo; Karen S Sfanos; Janielle P Maynard
Journal:  Front Oncol       Date:  2022-04-27       Impact factor: 5.738

3.  Loss of Myeloid BMPR1a Alters Differentiation and Reduces Mouse Prostate Cancer Growth.

Authors:  Claire L Ihle; Desiree M Straign; Meredith D Provera; Sergey V Novitskiy; Philip Owens
Journal:  Front Oncol       Date:  2020-04-07       Impact factor: 6.244
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.