Eslam Samaha1, Mohammad A Helwani1, Jamie C Brown1, Frank Brown1, Allan S Jaffe2, Mitchell G Scott3, Peter Nagele4. 1. Division of Clinical and Translational Research, Department of Anesthesiology, Washington University School of Medicine in St. Louis, United States. 2. Cardiovascular Division, Department of Internal Medicine, Division of Core Clinical Laboratory Services, Mayo Clinic and Medical School, Department of Laboratory Medicine and Pathology, Mayo Clinic and Medical School, Rochester, MN, United States. 3. Department of Pathology & Immunology (MGS), Washington University School of Medicine in St. Louis, United States. 4. Division of Clinical and Translational Research, Department of Anesthesiology, Washington University School of Medicine in St. Louis, United States. Electronic address: nagelep@wustl.edu.
Abstract
BACKGROUND: It is unclear if cardiac troponin values are stable in patients prior to undergoing non-cardiac surgery, or if they tend to rise towards the day of surgery. METHODS: In this small pilot study (n=18) among patients with cardiac risk undergoing non-cardiac surgery, we determined if high-sensitivity cardiac troponin I (hscTnI) changes between the preoperative clinic visit and the day of surgery. HscTnI was measured on an Abbott Architect STAT (Abbott Laboratories, USA) platform. RESULTS: The mean duration between preoperative clinic visit and day of surgery was 8.7±2.8 (SD) days. Median hscTnI was 3.4ng/L [2.0-4.8, IQR] at the preoperative visit and 2.8ng/L [2.3-4.4] on the day of surgery (mean difference-0.24ng/L, 95% CI - 0.73 to 0.24ng/L, p=0.30). Only one patient had a large change (>50%) along with symptoms. DISCUSSION: Evidence from this small study suggests that cardiac troponin values are stable in most high-risk patients, absent clinical events, within 10days prior to non-cardiac surgery.
BACKGROUND: It is unclear if cardiac troponin values are stable in patients prior to undergoing non-cardiac surgery, or if they tend to rise towards the day of surgery. METHODS: In this small pilot study (n=18) among patients with cardiac risk undergoing non-cardiac surgery, we determined if high-sensitivity cardiac troponin I (hscTnI) changes between the preoperative clinic visit and the day of surgery. HscTnI was measured on an Abbott Architect STAT (Abbott Laboratories, USA) platform. RESULTS: The mean duration between preoperative clinic visit and day of surgery was 8.7±2.8 (SD) days. Median hscTnI was 3.4ng/L [2.0-4.8, IQR] at the preoperative visit and 2.8ng/L [2.3-4.4] on the day of surgery (mean difference-0.24ng/L, 95% CI - 0.73 to 0.24ng/L, p=0.30). Only one patient had a large change (>50%) along with symptoms. DISCUSSION: Evidence from this small study suggests that cardiac troponin values are stable in most high-risk patients, absent clinical events, within 10days prior to non-cardiac surgery.
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