Heather J Bigham1, Teresa E Flaxman2, Andrew J J Smith3, Daniel L Benoit4. 1. School of Human Kinetics, University of Ottawa, Canada. Electronic address: heather.jb@hotmail.com. 2. School of Rehabilitation Sciences, University of Ottawa, Canada. Electronic address: teresa.flaxman@gmail.com. 3. School of Human Kinetics, University of Ottawa, Canada. Electronic address: ajjsmith16@gmail.com. 4. School of Human Kinetics, University of Ottawa, Canada; School of Rehabilitation Sciences, University of Ottawa, Canada. Electronic address: dbenoit@uottawa.ca.
Abstract
BACKGROUND: Females exhibit significantly greater incidence, prevalence, and severity of osteoarthritis (OA) compared to males. Despite known biological, morphological, and functional differences between males and females, there has been little sex-related investigation into sex-specific biomechanical and neuromuscular responses to OA. OBJECTIVE: To identify sex-related differences in OA-affected adults and within-sex differences between healthy and OA-affected adults' muscular activation patterns during lower limb loading. METHODS: Thirty adults with OA and 36 controls completed a standing ground reaction force (GRF) matching protocol requiring participants to expose equal body weight to each leg and modulate horizontal GRFs while maintaining constant joint positions. Electromyography was plotted as a function of GRF direction to depict muscle activation patterns. Muscles were classified as a general joint stabilizer, specific joint stabilizer or moment actuator by quantifying activation patterns with a test of asymmetry, specificity index and mean direction of activity. Lower limb kinematics and kinetics were also recorded. RESULTS: In general, muscle roles as it relates to joint stability did not differ between groups. Compared to controls, both males and females with OA demonstrated greater rectus femoris activity and reduced knee rotation moments. Females with OA had significantly greater biceps femoris and gastrocnemius activity during respective lateral, and anterior-medial loading directions compared to males with OA. CONCLUSIONS: We identified fundamental differences in muscular stabilization strategies in older adults with OA as well as sex-related changes in neuromuscular function that may influence joint loading conditions and provide insight into the greater incidence of knee OA in females.
BACKGROUND: Females exhibit significantly greater incidence, prevalence, and severity of osteoarthritis (OA) compared to males. Despite known biological, morphological, and functional differences between males and females, there has been little sex-related investigation into sex-specific biomechanical and neuromuscular responses to OA. OBJECTIVE: To identify sex-related differences in OA-affected adults and within-sex differences between healthy and OA-affected adults' muscular activation patterns during lower limb loading. METHODS: Thirty adults with OA and 36 controls completed a standing ground reaction force (GRF) matching protocol requiring participants to expose equal body weight to each leg and modulate horizontal GRFs while maintaining constant joint positions. Electromyography was plotted as a function of GRF direction to depict muscle activation patterns. Muscles were classified as a general joint stabilizer, specific joint stabilizer or moment actuator by quantifying activation patterns with a test of asymmetry, specificity index and mean direction of activity. Lower limb kinematics and kinetics were also recorded. RESULTS: In general, muscle roles as it relates to joint stability did not differ between groups. Compared to controls, both males and females with OA demonstrated greater rectus femoris activity and reduced knee rotation moments. Females with OA had significantly greater biceps femoris and gastrocnemius activity during respective lateral, and anterior-medial loading directions compared to males with OA. CONCLUSIONS: We identified fundamental differences in muscular stabilization strategies in older adults with OA as well as sex-related changes in neuromuscular function that may influence joint loading conditions and provide insight into the greater incidence of knee OA in females.
Authors: Natália Valdrighi; Juliana P Vago; Arjen B Blom; Fons A J van de Loo; Esmeralda N Blaney Davidson Journal: Front Pharmacol Date: 2022-05-19 Impact factor: 5.988