Ning-Ya Yang1, Chen-Ying Wang2, I-Tsu Chyuan3, King-Jean Wu2, Yu-Kang Tu4, Ching-Wen Chang2, Ping-Ning Hsu5, Mark Yen-Ping Kuo2, Yi-Wen Chen6. 1. Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Department of Periodontology, National Taiwan University Hospital, Taipei, Taiwan; Division of Periodontology, Department of Dentistry, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan. 2. Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Department of Periodontology, National Taiwan University Hospital, Taipei, Taiwan. 3. Department of Internal Medicine, Cathay General Hospital, Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan. 4. Graduate Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan. 5. Graduate Institute of Immunology, College of Medicine, National Taiwan University, Department of Internal Medicine, National Taiwan University Hospital, Taiwan. 6. Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Department of Periodontology, National Taiwan University Hospital, Taipei, Taiwan. Electronic address: yiwenchen@ntu.edu.tw.
Abstract
BACKGROUND/ PURPOSE: Chronic periodontitis (CP) and rheumatoid arthritis (RA) are the most common chronic inflammatory diseases and their immunopathogenesis is similar. The aim of this study was to evaluate the effect of non-surgical periodontal treatment on the serum levels of RA-related inflammatory markers in patients with chronic periodontitis. METHODS: Thirty-one Taiwanese adults with CP were included. Demographics and periodontal parameters, including probing depth, clinical attachment level, and number of remaining teeth in the oral cavity, were recorded. All subjects received non-surgical periodontal treatment such as scaling and subgingival root planing. Serum samples were collected before and after the treatment. Serum levels of anti-citrullinated protein antibodies (ACPA), rheumatoid factor, tumor necrosis factor-α (TNF-α), C-reactive protein, interleukin-1β (IL-1β), and Interleukin-6 (IL-6) were measured using an enzyme-linked immunosorbent assay. RESULTS: Non-surgical periodontal treatment significantly reduced the serum ACPA (p = 0.015) and TNF-α levels (p = 0.026) in CP patients, particularly in patients with generalized CP. Furthermore, there was a significant and positive correlation between the number of extracted teeth and the reduction in the serum ACPA (p = 0.05) and IL-1β levels (p = 0.029) after non-surgical periodontal treatment. CONCLUSION: Non-surgical periodontal therapy may aid in the control of RA-related inflammatory markers in patients with CP. A large-scale study with well-defined populations is needed to clarify the benefit of non-surgical periodontal therapy.
BACKGROUND/ PURPOSE:Chronic periodontitis (CP) and rheumatoid arthritis (RA) are the most common chronic inflammatory diseases and their immunopathogenesis is similar. The aim of this study was to evaluate the effect of non-surgical periodontal treatment on the serum levels of RA-related inflammatory markers in patients with chronic periodontitis. METHODS: Thirty-one Taiwanese adults with CP were included. Demographics and periodontal parameters, including probing depth, clinical attachment level, and number of remaining teeth in the oral cavity, were recorded. All subjects received non-surgical periodontal treatment such as scaling and subgingival root planing. Serum samples were collected before and after the treatment. Serum levels of anti-citrullinated protein antibodies (ACPA), rheumatoid factor, tumor necrosis factor-α (TNF-α), C-reactive protein, interleukin-1β (IL-1β), and Interleukin-6 (IL-6) were measured using an enzyme-linked immunosorbent assay. RESULTS: Non-surgical periodontal treatment significantly reduced the serum ACPA (p = 0.015) and TNF-α levels (p = 0.026) in CP patients, particularly in patients with generalized CP. Furthermore, there was a significant and positive correlation between the number of extracted teeth and the reduction in the serum ACPA (p = 0.05) and IL-1β levels (p = 0.029) after non-surgical periodontal treatment. CONCLUSION: Non-surgical periodontal therapy may aid in the control of RA-related inflammatory markers in patients with CP. A large-scale study with well-defined populations is needed to clarify the benefit of non-surgical periodontal therapy.
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