Literature DB >> 29173000

The central dogma, "GMO" and defective epistemology.

Giovanni Tagliabue1.   

Abstract

The expression "Genetically Modified Organisms" was coined to indicate a group of agricultural products (mostly crops and vegetables), modified through direct DNA recombination in order to obtain useful phenotypic traits or to inhibit undesirable characteristics. But the border between rDNA ("GMO") and other biotech methods is blurred. Moreover, the ill-assorted group is frequently charged with having peculiar, negative characteristics: many activists, part of the public and a few social science scholars think that "GMOs" are all dubious, even inherently dangerous. However, theoretical justifications of this alleged problematic nature which is supposed to be necessarily linked to the "splicing" of DNA, only when applied to agricultural products, are missing: the only text which tries to go in depth on the subject, an article by biologist Barry Commoner, takes aim at the wrong target, misunderstanding the Central Dogma. "GMO" is a term that has no clear reference, let alone in a detrimental sense. The only attempt to give it epistemological dignity fails.

Keywords:  Barry Commoner; Biotechnology; Central Dogma; Epistemology; Francis Crick; GMO safety

Mesh:

Year:  2017        PMID: 29173000      PMCID: PMC5790417          DOI: 10.1080/21645698.2017.1405899

Source DB:  PubMed          Journal:  GM Crops Food        ISSN: 2164-5698            Impact factor:   3.074


  11 in total

1.  Wag the dogma.

Authors: 
Journal:  Nat Genet       Date:  2002-04       Impact factor: 38.330

2.  Codex guidelines for GM foods include the analysis of unintended effects.

Authors:  Alexander G Haslberger
Journal:  Nat Biotechnol       Date:  2003-07       Impact factor: 54.908

3.  On protein synthesis.

Authors:  F H CRICK
Journal:  Symp Soc Exp Biol       Date:  1958

4.  The nonsensical GMO pseudo-category and a precautionary rabbit hole.

Authors:  Giovanni Tagliabue
Journal:  Nat Biotechnol       Date:  2015-09       Impact factor: 54.908

5.  The delitto perfetto approach to in vivo site-directed mutagenesis and chromosome rearrangements with synthetic oligonucleotides in yeast.

Authors:  Francesca Storici; Michael A Resnick
Journal:  Methods Enzymol       Date:  2006       Impact factor: 1.600

6.  The genome of cultivated sweet potato contains Agrobacterium T-DNAs with expressed genes: An example of a naturally transgenic food crop.

Authors:  Tina Kyndt; Dora Quispe; Hong Zhai; Robert Jarret; Marc Ghislain; Qingchang Liu; Godelieve Gheysen; Jan F Kreuze
Journal:  Proc Natl Acad Sci U S A       Date:  2015-04-20       Impact factor: 11.205

Review 7.  Genomic misconception: a fresh look at the biosafety of transgenic and conventional crops. A plea for a process agnostic regulation.

Authors:  Klaus Ammann
Journal:  N Biotechnol       Date:  2013-05-15       Impact factor: 5.079

8.  Central dogma of molecular biology.

Authors:  F Crick
Journal:  Nature       Date:  1970-08-08       Impact factor: 49.962

9.  Phytophotodermatitis from celery among grocery store workers.

Authors:  P J Seligman; C G Mathias; M A O'Malley; R C Beier; L J Fehrs; W S Serrill; W E Halperin
Journal:  Arch Dermatol       Date:  1987-11

10.  Investigation of residual DNAs in sugar from sugar beet (Beta vulgaris L.).

Authors:  Taichi Oguchi; Mari Onishi; Yukie Chikagawa; Takashi Kodama; Emiri Suzuki; Masaki Kasahara; Hiroshi Akiyama; Reiko Teshima; Satoshi Futo; Akihiro Hino; Satoshi Furui; Kazumi Kitta
Journal:  Shokuhin Eiseigaku Zasshi       Date:  2009-02       Impact factor: 0.464

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