César A Agostinis-Sobrinho1, Robinson Ramírez-Vélez2, Antonio García-Hermoso3, Carla Moreira1, Luís Lopes1, José Oliveira-Santos1, Sandra Abreu1, Jorge Mota1, Rute Santos1,4. 1. Faculty of Sport, Research Centre in Physical Activity, Health and Leisure, University of Porto, Porto, Portugal. 2. School of Medicine and Health Sciences, Center for the Study of Physical Activity Measurement (CEMA), Universidad del Rosario, Bogotá, Colombia. 3. Physical Activity, Sport and Health Sciences Laboratory, University of Santiago de Chile, Santiago de Chile, Chile. 4. School of Education, Faculty of Social Sciences, Early Start Research Institute. University of Wollongong, Wollongong, New South Wales, Australia.
Abstract
BACKGROUND: Low muscular fitness (MF) and low-grade inflammation has been linked to insulin resistance (IR). OBJECTIVE: To evaluate the associations between MF and a clustered score of inflammatory biomarkers on IR and to investigate the combined impact of MF and inflammation on IR in adolescents. METHODS: This is a cross-sectional analysis with 529 adolescents (267 girls) aged 12 to 18 years. Pubertal stage, socioeconomic status, adherence to the Mediterranean diet, cardiorespiratory fitness, and waist circumference were assessed. Standing long-jump and isometric handgrip dynamometry were used as indicators of MF. Continuous score of clustered inflammatory biomarkers (InflaScore) (sum of Z-scores of C-reactive protein, C3, C4, fibrinogen, and leptin) and IR (homeostasis model assessment of insulin resistance [HOMA-IR] estimated from fasting serum insulin and glucose) were assessed. RESULTS: HOMA-IR and fasting insulin were positively associated with InflaScore and negatively associated with MF, independently of age, sex, pubertal stage, socioeconomic status, adherence to the Mediterranean diet, cardiorespiratory fitness, and waist circumference. Adolescents classified as High InflaScore/Unfit showed significantly higher HOMA-IR when compared than those with High InflaScore/Fit and those with Low InflaScore/Fit (F(3,519) = 4.761, P < .003), after adjustments for potential confounders. Unfit adolescents with high InflaScore had the highest odds of expressing high HOMA-IR (odds ratio, OR = 2.40, 95% confidence interval [CI]: 1.2-5.6) and insulin risk (2.53 95% CI, 1.5-5.9) when compared to those of the Low InflaScore/Fit group, after adjustments for potential confounders. CONCLUSION: Higher levels of MF seem to minimize the deleterious effect of inflammation on IR.
BACKGROUND:Low muscular fitness (MF) and low-grade inflammation has been linked to insulin resistance (IR). OBJECTIVE: To evaluate the associations between MF and a clustered score of inflammatory biomarkers on IR and to investigate the combined impact of MF and inflammation on IR in adolescents. METHODS: This is a cross-sectional analysis with 529 adolescents (267 girls) aged 12 to 18 years. Pubertal stage, socioeconomic status, adherence to the Mediterranean diet, cardiorespiratory fitness, and waist circumference were assessed. Standing long-jump and isometric handgrip dynamometry were used as indicators of MF. Continuous score of clustered inflammatory biomarkers (InflaScore) (sum of Z-scores of C-reactive protein, C3, C4, fibrinogen, and leptin) and IR (homeostasis model assessment of insulin resistance [HOMA-IR] estimated from fasting serum insulin and glucose) were assessed. RESULTS: HOMA-IR and fasting insulin were positively associated with InflaScore and negatively associated with MF, independently of age, sex, pubertal stage, socioeconomic status, adherence to the Mediterranean diet, cardiorespiratory fitness, and waist circumference. Adolescents classified as High InflaScore/Unfit showed significantly higher HOMA-IR when compared than those with High InflaScore/Fit and those with Low InflaScore/Fit (F(3,519) = 4.761, P < .003), after adjustments for potential confounders. Unfit adolescents with high InflaScore had the highest odds of expressing high HOMA-IR (odds ratio, OR = 2.40, 95% confidence interval [CI]: 1.2-5.6) and insulin risk (2.53 95% CI, 1.5-5.9) when compared to those of the Low InflaScore/Fit group, after adjustments for potential confounders. CONCLUSION: Higher levels of MF seem to minimize the deleterious effect of inflammation on IR.
Authors: Tiago Rodrigues de Lima; Priscila Custódio Martins; Yara Maria Franco Moreno; Jean-Philippe Chaput; Mark Stephen Tremblay; Xuemei Sui; Diego Augusto Santos Silva Journal: Sports Med Date: 2022-01-12 Impact factor: 11.928
Authors: Julio Cesar Amado-Pacheco; Daniel Humberto Prieto-Benavides; Jorge Enrique Correa-Bautista; Antonio García-Hermoso; César Agostinis-Sobrinho; Alicia María Alonso-Martínez; Mikel Izquierdo; Robinson Ramírez-Vélez Journal: Int J Environ Res Public Health Date: 2019-08-23 Impact factor: 3.390
Authors: Ryan A Williams; Simon B Cooper; Karah J Dring; Lorna Hatch; John G Morris; Feng-Hua Sun; Mary E Nevill Journal: BMC Pediatr Date: 2022-02-02 Impact factor: 2.125