Literature DB >> 2917002

Molecular cloning and nucleotide sequence of human pancreatic prechymotrypsinogen cDNA.

N Tomita1, Y Izumoto, A Horii, S Doi, H Yokouchi, M Ogawa, T Mori, K Matsubara.   

Abstract

The cDNA clone encoding human prechymotrypsinogen was isolated from a human pancreas cDNA library and its nucleotide sequence was determined. The sequence consists of a 16 bp 5' non-coding region, a 789 bp amino acid coding region and a 60 bp 3' non-coding region. The predicted product consists of 263 amino acids, including 18 amino acids for a signal peptide and 15 amino acids possible for an activation peptide. Southern blot analyses using the cloned cDNA as a probe revealed that human genomic DNA carries at least two genes that are related to chymotrypsinogen.

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Year:  1989        PMID： 2917002     DOI： 10.1016/s0006-291x(89)80087-7

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  8 in total

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4.  Genomic cloning and partial characterization of human chymotrypsinogen gene.

Authors:  D X Hou; K Ozawa; N Tomita; Y Maeda; T Hashiguchi; K Yokoyama; E Soeda
Journal:  Jpn J Hum Genet       Date:  1993-12

5.  Genes for mast-cell serine protease and their molecular evolution.

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6.  Arg236 in human chymotrypsin B2 (CTRB2) is a key determinant of high enzyme activity, trypsinogen degradation capacity, and protection against pancreatitis.

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7.  Secretory granule proteases in rat mast cells. Cloning of 10 different serine proteases and a carboxypeptidase A from various rat mast cell populations.

Authors:  C Lützelschwab; G Pejler; M Aveskogh; L Hellman
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8.  Detection of the pancreas-specific gene in the peripheral blood of patients with pancreatic carcinoma.

Authors:  T Kuroki; T Tomioka; Y Tajima; K Inoue; Y Ikematsu; K Ichinose; J Furui; T Kanematsu
Journal:  Br J Cancer       Date:  1999-09       Impact factor: 7.640
  8 in total

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