| Literature DB >> 29168246 |
Ji-Sun Shin1, Soo-Hak Chung2, Woo-Seok Lee1,3, Je-Young Lee2, Jong-Lae Kim2, Kyung-Tae Lee1,3.
Abstract
The medicinal mushroom Cordyceps militaris has been reported to possess anticancer and immunomodulatory effects. We investigated the immunostimulatory effects of culture supernatant of C. militaris (WIB-801CE) by examining its in vitro enhancing effects on cell proliferation and cytokine releases in splenocytes and its in vivo effects on cyclophosphamide-induced immunosuppressed mice. WIB-801CE enhanced normal and methotrexate-induced cell proliferation. WIB-801CE significantly ameliorated interleukin (IL)-2, interferon-γ, and tumor necrosis factor-α secretion in methotrexate-induced splenocytes. Oral administration of WIB-801CE effectively increased the cyclophosphamide-suppressed splenocyte proliferation and natural killer cytotoxic activity. WIB-801CE effectively recovered cyclophosphamide-induced decreases in IL-2, interferon-γ, tumor necrosis factor-α, and IL-10 level. The collective data implicate WIB-801CE as a therapeutic candidate in ameliorating the immunosuppression through immunostimulatory properties.Entities:
Keywords: Cordyceps militaris; cyclophosphamide; immunostimulatory activitiy; splenocyte
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Year: 2017 PMID： 29168246 DOI： 10.1002/ptr.5960
Source DB: PubMed Journal: Phytother Res ISSN： 0951-418X Impact factor: 5.878