Ramfis Nieto-Martínez1,2,3, Juan P González-Rivas4, José R Medina-Inojosa5, Hermes Florez6,7. 1. Geriatric Research, Education, and Clinical Center (GRECC) and South Florida Veterans Affairs Foundation for Research & Education, Miami VA Healthcare System, Miami, FL, USA. ramfis.nieto-martinez@va.gov. 2. Department of Physiology, School of Medicine, University Centro-Occidental "Lisandro Alvarado" and Cardio-metabolic Unit 7, Barquisimeto, Venezuela. ramfis.nieto-martinez@va.gov. 3. Miami Veterans Affairs Medical Center, 1201 Northwest 16th Street, CLC 207, Miami, FL, 33125, USA. ramfis.nieto-martinez@va.gov. 4. The Andes Clinic of Cardio-Metabolic Studies, Mérida, Venezuela. 5. Division of Preventive Cardiology, Department of Cardiovascular Medicine. Mayo Clinic, Rochester, MN, USA. 6. Geriatric Research, Education, and Clinical Center (GRECC) and South Florida Veterans Affairs Foundation for Research & Education, Miami VA Healthcare System, Miami, FL, USA. 7. Departments of Public Health Sciences and Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.
Abstract
RECENT FINDINGS: Eating disorders (ED) affect energy intake modifying body fat depots. Prior evidence suggests that binge eating disorder (BED) and bulimia nervosa (BN) could increase the risk for type 2 diabetes (T2D), while anorexia nervosa (AN) could reduce it. PURPOSE OF REVIEW: A systematic review and meta-analysis were conducted to evaluate if ED are risk factors for T2D. Ten studies were selected out of 1057 screened. Meta-analysis of six studies with T2D as outcome is reported. Among cross-sectional studies, both BED (OR 3.69, 95% CI [1.12-12.12]) and BN (OR 3.45 [1.92-6.1]) increased the risk of T2D, while AN was not associated with lower risk (OR 0.87 [0.40-1.88]). Cohort studies showed increased risk of T2D with BN (RR 1.7 [1.2-2.5]), and decreased risk with AN (RR 0.71 [0.52-0.98]), but for BED the association was less clear (OR 3.34 [0.85-13.12]). Limitations of studies and recommendations for future research are presented.
RECENT FINDINGS:Eating disorders (ED) affect energy intake modifying body fat depots. Prior evidence suggests that binge eating disorder (BED) and bulimia nervosa (BN) could increase the risk for type 2 diabetes (T2D), while anorexia nervosa (AN) could reduce it. PURPOSE OF REVIEW: A systematic review and meta-analysis were conducted to evaluate if ED are risk factors for T2D. Ten studies were selected out of 1057 screened. Meta-analysis of six studies with T2D as outcome is reported. Among cross-sectional studies, both BED (OR 3.69, 95% CI [1.12-12.12]) and BN (OR 3.45 [1.92-6.1]) increased the risk of T2D, while AN was not associated with lower risk (OR 0.87 [0.40-1.88]). Cohort studies showed increased risk of T2D with BN (RR 1.7 [1.2-2.5]), and decreased risk with AN (RR 0.71 [0.52-0.98]), but for BED the association was less clear (OR 3.34 [0.85-13.12]). Limitations of studies and recommendations for future research are presented.
Entities:
Keywords:
Anorexia nervosa; Binge eating disorder; Bulimia nervosa; Diabetes mellitus type 2; Eating disorders; Night eating syndrome
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