F Cesari1, F Sofi2, R Molino Lova3, F Vannetti3, G Pasquini3, F Cecchi3, R Marcucci4, A M Gori4, C Macchi5. 1. Central Laboratory, Careggi University Hospital, Florence, Italy. 2. Department of Experimental and Clinical Medicine, University of Florence, Italy; Clinical Nutrition Unit, Careggi University Hospital, Florence, Italy; Don Carlo Gnocchi Foundation, Onlus IRCCS, Florence, Italy. Electronic address: francescosofi@gmail.com. 3. Don Carlo Gnocchi Foundation, Onlus IRCCS, Florence, Italy. 4. Department of Experimental and Clinical Medicine, University of Florence, Italy; Unit of Atherothrombotic Diseases, Careggi University Hospital, Florence, Italy. 5. Department of Experimental and Clinical Medicine, University of Florence, Italy; Don Carlo Gnocchi Foundation, Onlus IRCCS, Florence, Italy.
Abstract
BACKGROUND AND AIM: Adherence to the Mediterranean Diet (MD) has been associated with a longer and better life. The aim of this study was to examine the effects of adherence to the MD, and of nutritional habits on endothelial progenitor (EPCs) and circulating progenitor (CPCs) cells in a cohort of nonagenarians enrolled within the Mugello Study, an epidemiological study aimed at investigating both clinically relevant geriatric items and various health issues, including those related to nutritional status. METHODS AND RESULTS: Four hundred twenty-one nonagenarians (306 F, 115 M, mean age: 93.1 ± 3.2 years) were evaluated. Adherence to MD was assessed through the Mediterranean Diet Score. Elderly subjects who were in the fourth quartile of the Mediterranean diet score showed significantly higher EPCs than subjects grouped into the other three quartiles. After adjustment for confounders, elderly subjects who were in the highest quartile of adherence to the MD score reported to have EPCs' levels significantly higher than those who reported lower values of adherence to the MD. Furthermore, by analyzing different food categories, it was reported that daily consumption of olive oil and a higher consumption of fruit and vegetables showed higher CPCs CD34+ and EPCs CD34+/KDR+ than subjects with not daily or lower consumption. CONCLUSION: Our results support the hypothesis that the adherence to MD, as well as a daily consumption of olive oil and fruit and vegetables, characteristics of MD, may protect against the development of endothelial dysfunction through increasing EPCs and CPCs in older age.
BACKGROUND AND AIM: Adherence to the Mediterranean Diet (MD) has been associated with a longer and better life. The aim of this study was to examine the effects of adherence to the MD, and of nutritional habits on endothelial progenitor (EPCs) and circulating progenitor (CPCs) cells in a cohort of nonagenarians enrolled within the Mugello Study, an epidemiological study aimed at investigating both clinically relevant geriatric items and various health issues, including those related to nutritional status. METHODS AND RESULTS: Four hundred twenty-one nonagenarians (306 F, 115 M, mean age: 93.1 ± 3.2 years) were evaluated. Adherence to MD was assessed through the Mediterranean Diet Score. Elderly subjects who were in the fourth quartile of the Mediterranean diet score showed significantly higher EPCs than subjects grouped into the other three quartiles. After adjustment for confounders, elderly subjects who were in the highest quartile of adherence to the MD score reported to have EPCs' levels significantly higher than those who reported lower values of adherence to the MD. Furthermore, by analyzing different food categories, it was reported that daily consumption of olive oil and a higher consumption of fruit and vegetables showed higher CPCs CD34+ and EPCs CD34+/KDR+ than subjects with not daily or lower consumption. CONCLUSION: Our results support the hypothesis that the adherence to MD, as well as a daily consumption of olive oil and fruit and vegetables, characteristics of MD, may protect against the development of endothelial dysfunction through increasing EPCs and CPCs in older age.
Authors: Mario Siervo; John C Mathers; Oliver M Shannon; Ammar W Ashor; Filippo Scialo; Gabriele Saretzki; Carmen Martin-Ruiz; Jose Lara; Jamie Matu; Alex Griffiths; Natassia Robinson; Lionetti Lillà; Emma Stevenson; Blossom C M Stephan; Anne Marie Minihane Journal: Eur J Clin Nutr Date: 2021-01-29 Impact factor: 4.884
Authors: Marta GómezSánchez; Leticia Gómez Sánchez; Maria C Patino-Alonso; Rosario Alonso-Domínguez; Natalia Sánchez-Aguadero; Cristina Lugones-Sánchez; Emiliano Rodríguez Sánchez; Luis García Ortiz; Manuel A Gómez-Marcos Journal: Nutrients Date: 2020-04-08 Impact factor: 5.717