| Literature DB >> 29165633 |
Brad R Rosenberg1,2, Catherine A Freije1, Naoko Imanaka3, Spencer T Chen1, Jennifer L Eitson2, Rachel Caron1, Skyler A Uhl1, Marija Zeremski4, Andrew Talal4, Ira M Jacobson4, Charles M Rice3, John W Schoggins5.
Abstract
Polymorphisms at IFNL4 strongly influence spontaneous resolution and interferon therapeutic response in hepatitis C virus (HCV) infection. In chronic HCV, unfavorable alleles are associated with elevated interferon (IFN)-stimulated gene (ISG) expression in the liver, but extrahepatic effects are less well characterized. We used RNA sequencing (RNA-Seq) to examine whether IFNL4 genetic variation (rs368234815) modulates ISG expression in peripheral blood mononuclear cells (PBMC) during chronic HCV infection. ISG expression was elevated in unstimulated PBMC homozygous for the unfavorable ΔG IFNL4 variant; expression following IFN-α stimulation was comparable across genotypes. These findings suggest that lambda interferons may have broader systemic effects during HCV infection.Entities:
Keywords: Hepatitis C; IFNL4; interferon; interferon-stimulated genes; peripheral blood mononuclear cells
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Year: 2018 PMID： 29165633 PMCID： PMC5853921 DOI： 10.1093/infdis/jix593
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226