| Literature DB >> 29165220 |
Nilda E Rodríguez1, Iraci D Lima2,3, Upasna Gaur Dixit4, Elizabeth A Turcotte1, Ryan D Lockard1, Hemali Batra-Sharma5, Eliana L Nascimento6,7,2, Selma M B Jeronimo8,2,6,7, Mary E Wilson9,10,4.
Abstract
Leishmania infantum causes visceral leishmaniasis (VL) in Brazil. We previously observed that VL is more common in males than females living in endemic neighborhoods, despite similar exposure. Using a larger sample, we document that VL is more common in males than females, but only after puberty. BALB/c and C57BL/6 mouse models confirmed that there is a biological basis for male susceptibility to symptomatic VL, showing higher parasite burdens in males than females. Female C57BL/6 mice generated more antigen-induced cytokines associated with curative responses (interferon-γ, interleukin [IL]-1β). Males expressed higher levels of IL-10 and tumor necrosis factor, which are linked to exacerbated disease. Different parasite lines entered or survived at a higher rate in macrophages of male- than female-origin. These results suggest that males are inherently more susceptible to L. infantum than females and that mice are a valid model to study this sex-dependent difference.Entities:
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Year: 2018 PMID： 29165220 PMCID： PMC5928733 DOI： 10.4269/ajtmh.17-0563
Source DB: PubMed Journal: Am J Trop Med Hyg ISSN： 0002-9637 Impact factor: 2.345