Literature DB >> 2915978

Expression of delta-aminolevulinate synthase in avian cells: separate genes encode erythroid-specific and nonspecific isozymes.

R D Riddle1, M Yamamoto, J D Engel.   

Abstract

A controversy has existed in the literature for the past several years regarding the number of vertebrate genes encoding the mitochondrial protein that initiates the first step in heme biosynthesis, delta-aminolevulinate synthase [ALAS; succinyl-CoA: glycine C-succinyltransferase (decarboxylating), EC 2.3.1.37]. By analysis of chicken ALAS cDNA clones isolated from both liver and erythroid cells, we show that at least two separate genes encode ALAS mRNAs. These experiments show that (i) two different genes encode the ALAS isozymes found in erythroid and in liver tissues, and (ii) while the product of the erythroid gene (ALASE) is expressed exclusively in erythroid cells, the hepatic form of the enzyme is expressed ubiquitously, suggesting that this is the nonspecific form (ALASN) found in all chicken tissues.

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Year:  1989        PMID： 2915978      PMCID： PMC286563          DOI： 10.1073/pnas.86.3.792

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  34 in total

1.  Induction of -aminolevulinic acid synthetase in chick embryo liver cells in cluture.

Authors:  S Sassa; S Granick
Journal:  Proc Natl Acad Sci U S A       Date:  1970-10       Impact factor: 11.205

2.  Studies on the role of heme in the regulation of delta-aminolevulinic acid synthetase during fetal hepatic development.

Authors:  J S Woods
Journal:  Mol Pharmacol       Date:  1974-05       Impact factor: 4.436

3.  Determination of the molecular weight of detergent-solubilized enzymes by sedimentation equilibrium in an air-driven ultracentrifuge.

Authors:  G J Howlett; H Birch; P W Dickson; G Schreiber
Journal:  Biochem Biophys Res Commun       Date:  1982-04-14       Impact factor: 3.575

4.  Number and evolutionary conservation of alpha- and beta-tubulin and cytoplasmic beta- and gamma-actin genes using specific cloned cDNA probes.

Authors:  D W Cleveland; M A Lopata; R J MacDonald; N J Cowan; W J Rutter; M W Kirschner
Journal:  Cell       Date:  1980-05       Impact factor: 41.582

Review 5.  Regulation by heme of synthesis and intracellular translocation of delta-aminolevulinate synthase in the liver.

Authors:  G Kikuchi; N Hayashi
Journal:  Mol Cell Biochem       Date:  1981-06-09       Impact factor: 3.396

6.  Purification of 5-aminolaevulinate synthase from liver mitochondria of chick embryo.

Authors:  I A Borthwick; G Srivastava; J D Brooker; B K May; W H Elliott
Journal:  Eur J Biochem       Date:  1983-01-01

7.  Translocation of delta-aminolevulinate synthase from the cytosol to the mitochondria and its regulation by hemin in the rat liver.

Authors:  K Yamauchi; N Hayashi; G Kikuchi
Journal:  J Biol Chem       Date:  1980-02-25       Impact factor: 5.157

8.  Regulation of synthesis and intracellular translocation of delta-aminolevulinate synthase by heme and its relation to the heme saturation of tryptophan pyrrolase in rat liver.

Authors:  M Yamamoto; N Hayashi; G Kikuchi
Journal:  Arch Biochem Biophys       Date:  1981-07       Impact factor: 4.013

9.  Evidence for erythroid and nonerythroid forms of delta-aminolevulinate synthetase.

Authors:  D F Bishop; H Kitchen; W A Wood
Journal:  Arch Biochem Biophys       Date:  1981-02       Impact factor: 4.013

10.  DNA sequencing with chain-terminating inhibitors.

Authors:  F Sanger; S Nicklen; A R Coulson
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205
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  42 in total

1.  Two different genes encode delta-aminolevulinate synthase in humans: nucleotide sequences of cDNAs for the housekeeping and erythroid genes.

Authors:  D F Bishop
Journal:  Nucleic Acids Res       Date:  1990-12-11       Impact factor: 16.971

2.  Genetic regulation of delta-aminolevulinate dehydratase during erythropoiesis.

Authors:  T R Bishop; M W Miller; J Beall; L I Zon; P Dierks
Journal:  Nucleic Acids Res       Date:  1996-07-01       Impact factor: 16.971

3.  Erythroid 5-aminolevulinate synthase is located on the X chromosome.

Authors:  T C Cox; M J Bawden; N G Abraham; S S Bottomley; B K May; E Baker; L Z Chen; G R Sutherland
Journal:  Am J Hum Genet       Date:  1990-01       Impact factor: 11.025

4.  Enzymatic defect in "X-linked" sideroblastic anemia: molecular evidence for erythroid delta-aminolevulinate synthase deficiency.

Authors:  P D Cotter; M Baumann; D F Bishop
Journal:  Proc Natl Acad Sci U S A       Date:  1992-05-01       Impact factor: 11.205

Review 5.  5-Aminolevulinate synthase and the first step of heme biosynthesis.

Authors:  G C Ferreira; J Gong
Journal:  J Bioenerg Biomembr       Date:  1995-04       Impact factor: 2.945

Review 6.  Molecular defects of erythroid 5-aminolevulinate synthase in X-linked sideroblastic anemia.

Authors:  S S Bottomley; B K May; T C Cox; P D Cotter; D F Bishop
Journal:  J Bioenerg Biomembr       Date:  1995-04       Impact factor: 2.945

Review 7.  Heme biosynthesis and the porphyrias.

Authors:  John D Phillips
Journal:  Mol Genet Metab       Date:  2019-04-22       Impact factor: 4.797

8.  Structure of a mouse erythroid 5-aminolevulinate synthase gene and mapping of erythroid-specific DNAse I hypersensitive sites.

Authors:  D S Schoenhaut; P J Curtis
Journal:  Nucleic Acids Res       Date:  1989-09-12       Impact factor: 16.971

9.  Cloning and expression of chicken erythrocyte transglutaminase.

Authors:  N Weraarchakul-Boonmark; J M Jeong; S N Murthy; J D Engel; L Lorand
Journal:  Proc Natl Acad Sci U S A       Date:  1992-10-15       Impact factor: 11.205

10.  Structure and regulation of the chicken erythroid delta-aminolevulinate synthase gene.

Authors:  K C Lim; H Ishihara; R D Riddle; Z Yang; N Andrews; M Yamamoto; J D Engel
Journal:  Nucleic Acids Res       Date:  1994-04-11       Impact factor: 16.971
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