Literature DB >> 29158273

Revisiting Activation of and Mechanism of Resistance to Compound IQG-607 in Mycobacterium tuberculosis.

Bruno L Abbadi1,2, Anne D Villela3, Valnês S Rodrigues-Junior1, Fernanda T Subtil1,2, Pedro F Dalberto1,2, Ana P S Pinheiro1,2, Diógenes S Santos1,4, Pablo Machado1,4, Luiz A Basso1,2, Cristiano V Bizarro3,2.   

Abstract

IQG-607 is a metal complex previously reported as a promising anti-tuberculosis (TB) drug against isoniazid (INH)-resistant strains of Mycobacterium tuberculosis Unexpectedly, we found that INH-resistant clinical isolates were resistant to IQG-607. Spontaneous mutants resistant to IQG-607 were subjected to whole-genome sequencing, and all sequenced colonies carried alterations in the katG gene. The katG(S315T) mutation was sufficient to confer resistance to IQG-607 in both MIC assays and inside macrophages. Moreover, overexpression of the InhA(S94A) protein caused IQG-607's resistance.
Copyright © 2018 American Society for Microbiology.

Entities:  

Keywords:  MIC; antibiotic resistance; spontaneous mutants; tuberculosis; whole-genome sequencing

Mesh：

Substances：

Year:  2018        PMID： 29158273      PMCID： PMC5786794          DOI： 10.1128/AAC.02222-17

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  24 in total

1.  Screening and characterization of mutations in isoniazid-resistant Mycobacterium tuberculosis isolates obtained in Brazil.

Authors:  Rosilene Fressatti Cardoso; Robert C Cooksey; Glenn P Morlock; Patricia Barco; Leticia Cecon; Francisco Forestiero; Clarice Q F Leite; Daisy N Sato; Maria de Lourdes Shikama; Elsa M Mamizuka; Rosario D C Hirata; Mario H Hirata
Journal:  Antimicrob Agents Chemother       Date:  2004-09       Impact factor: 5.191

2.  Isoniazid metal complex reactivity and insights for a novel anti-tuberculosis drug design.

Authors:  Eduardo Henrique Silva Sousa; Luiz Augusto Basso; Diógenes S Santos; Izaura Cirino Nogueira Diógenes; Elisane Longhinotti; Luiz Gonzaga de França Lopes; Icaro de Sousa Moreira
Journal:  J Biol Inorg Chem       Date:  2011-09-28       Impact factor: 3.358

3.  The in vitro mechanisms of isoniazid and ethionamide resistance poorly reflect those in vivo in Mycobacterium tuberculosis.

Authors:  Florence Brossier; Emmanuelle Cambau; Emilie Tessier; Vincent Jarlier; Wladimir Sougakoff
Journal:  Tuberculosis (Edinb)       Date:  2016-09-29       Impact factor: 3.131

4.  In vitro interactions between new antitubercular drug candidates SQ109 and TMC207.

Authors:  Venkata M Reddy; Leo Einck; K Andries; Carol A Nacy
Journal:  Antimicrob Agents Chemother       Date:  2010-04-12       Impact factor: 5.191

5.  Toxicological profile of IQG-607 after single and repeated oral administration in minipigs: An essential step towards phase I clinical trial.

Authors:  Valnês S Rodrigues-Junior; Luciana Cintra; Pablo Machado; Adílio Dadda; Luiz Augusto Basso; Ana Carolina Cintra Nunes Mafra; Alexandre Holthausen Campos; Maria Martha Campos; Diógenes Santiago Santos
Journal:  Regul Toxicol Pharmacol       Date:  2017-08-23       Impact factor: 3.271

6.  Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid.

Authors:  Catherine Vilchèze; Feng Wang; Masayoshi Arai; Manzour Hernando Hazbón; Roberto Colangeli; Laurent Kremer; Torin R Weisbrod; David Alland; James C Sacchettini; William R Jacobs
Journal:  Nat Med       Date:  2006-08-13       Impact factor: 53.440

Review 7.  Hepatotoxicity mechanisms of isoniazid: A mini-review.

Authors:  Hozeifa M Hassan; Hong-Li Guo; Bashir A Yousef; Zhang Luyong; Jiang Zhenzhou
Journal:  J Appl Toxicol       Date:  2015-06-10       Impact factor: 3.446

8.  Crystal structure of Mycobacterium tuberculosis catalase-peroxidase.

Authors:  Thomas Bertrand; Nigel A J Eady; Jamie N Jones; Judit M Nagy; Brigitte Jamart-Grégoire; Emma Lloyd Raven; Katherine A Brown
Journal:  J Biol Chem       Date:  2004-07-01       Impact factor: 5.157

9.  IQG-607 abrogates the synthesis of mycolic acids and displays intracellular activity against Mycobacterium tuberculosis in infected macrophages.

Authors:  Valnês S Rodrigues-Junior; André A dos Santos Junior; Anne D Villela; Juan M Belardinelli; Héctor R Morbidoni; Luiz A Basso; Maria M Campos; Diógenes S Santos
Journal:  Int J Antimicrob Agents       Date:  2013-10-01       Impact factor: 5.283

10.  Resistant mutants of Mycobacterium tuberculosis selected in vitro do not reflect the in vivo mechanism of isoniazid resistance.

Authors:  Indra L Bergval; Anja R J Schuitema; Paul R Klatser; Richard M Anthony
Journal:  J Antimicrob Chemother       Date:  2009-07-04       Impact factor: 5.790
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  3 in total

1.  Pre-clinical evaluation of quinoxaline-derived chalcones in tuberculosis.

Authors:  Thaís C Muradás; Bruno L Abbadi; Anne D Villela; Fernanda S Macchi; Pedro F Bergo; Talita F de Freitas; Nathalia D M Sperotto; Luis F S M Timmers; Osmar Norberto de Souza; Jaqueline N Picada; Jean Fachini; Juliana Bondan da Silva; Nayara C P de Albuquerque; Maísa D Habenschus; Daniel B Carrão; Bruno A Rocha; Fernando Barbosa Junior; Anderson R M de Oliveira; Alessandra Mascarello; Patrícia Neuenfeldf; Ricardo J Nunes; Héctor R Morbidoni; Maria M Campos; Luiz A Basso; Valnês S Rodrigues-Junior
Journal:  PLoS One       Date:  2018-08-16       Impact factor: 3.240

Review 2.  Is IQG-607 a Potential Metallodrug or Metallopro-Drug With a Defined Molecular Target in Mycobacterium tuberculosis?

Authors:  Bruno L Abbadi; Valnês da Silva Rodrigues-Junior; Adilio da Silva Dadda; Kenia Pissinate; Anne D Villela; Maria M Campos; Luiz G de França Lopes; Cristiano V Bizarro; Pablo Machado; Eduardo H S Sousa; Luiz A Basso
Journal:  Front Microbiol       Date:  2018-05-01       Impact factor: 5.640

3.  Anti-tubercular profile of new selenium-menadione conjugates against Mycobacterium tuberculosis H37Rv (ATCC 27294) strain and multidrug-resistant clinical isolates.

Authors:  Ruan C B Ribeiro; Daniel B de Marins; Iris Di Leo; Luana da Silva Gomes; Matheus G de Moraes; Bruno L Abbadi; Anne D Villela; Wellington F da Silva; Luiz Cláudio R P da Silva; Pablo Machado; Cristiano Valim Bizarro; Luiz Augusto Basso; Marcela Cristina de Moraes; Vitor F Ferreira; Fernando de C da Silva; Vanessa Nascimento
Journal:  Eur J Med Chem       Date:  2020-09-23       Impact factor: 6.514
  3 in total

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