Literature DB >> 26095833

Hepatotoxicity mechanisms of isoniazid: A mini-review.

Hozeifa M Hassan1,2, Hong-Li Guo1, Bashir A Yousef1,3, Zhang Luyong1,4,5, Jiang Zhenzhou1,6,7.   

Abstract

Isoniazid (INH) is an antituberculosis drug associated with idiosyncratic liver injury in susceptible patients. INH-induced hepatotoxicity remains a significant clinical problem, but the underlying mechanisms are still unclear, despite the growing evidence that INH and/or its major metabolite, hydrazine, play an important role in hepatotoxicity.
Copyright © 2015 John Wiley & Sons, Ltd.

Entities:  

Keywords:  CYP2E1; hepatotoxicity mechanisms; isoniazid

Mesh：

Substances：

Year:  2015        PMID： 26095833     DOI： 10.1002/jat.3175

Source DB:  PubMed          Journal:  J Appl Toxicol        ISSN： 0260-437X            Impact factor:   3.446


  14 in total

1.  Establishment of a mouse model of enalapril-induced liver injury and investigation of the pathogenesis.

Authors:  Yuji Shirai; Shingo Oda; Sayaka Makino; Koichi Tsuneyama; Tsuyoshi Yokoi
Journal:  Lab Invest       Date:  2017-03-06       Impact factor: 5.662

2.  Role of Inflammatory and Oxidative Stress, Cytochrome P450 2E1, and Bile Acid Disturbance in Rat Liver Injury Induced by Isoniazid and Lipopolysaccharide Cotreatment.

Authors:  Hozeifa Mohamed Hassan; Hongli Guo; Bashir Alsiddig Yousef; Mounia Guerram; Aida Mejda Hamdi; Luyong Zhang; Zhenzhou Jiang
Journal:  Antimicrob Agents Chemother       Date:  2016-08-22       Impact factor: 5.191

3.  Revisiting Activation of and Mechanism of Resistance to Compound IQG-607 in Mycobacterium tuberculosis.

Authors:  Bruno L Abbadi; Anne D Villela; Valnês S Rodrigues-Junior; Fernanda T Subtil; Pedro F Dalberto; Ana P S Pinheiro; Diógenes S Santos; Pablo Machado; Luiz A Basso; Cristiano V Bizarro
Journal:  Antimicrob Agents Chemother       Date:  2018-01-25       Impact factor: 5.191

4.  Hepatotoxicity Induced by Isoniazid-Lipopolysaccharide through Endoplasmic Reticulum Stress, Autophagy, and Apoptosis Pathways in Zebrafish.

Authors:  Yun Zhang; Juan Cen; Zhili Jia; Chung-Der Hsiao; Qing Xia; Xue Wang; Xiqiang Chen; Rongchun Wang; Zhenzhou Jiang; Luyong Zhang; Kechun Liu
Journal:  Antimicrob Agents Chemother       Date:  2019-04-25       Impact factor: 5.191

5.  Evaluation of HepaRG cells for the assessment of indirect drug-induced hepatotoxicity using INH as a model substance.

Authors:  Anika Mann; Thomas Pelz; Knut Rennert; Alexander Mosig; Michael Decker; Amelie Lupp
Journal:  Hum Cell       Date:  2017-05-19       Impact factor: 4.174

6.  Genetic Variations Associated with Anti-Tuberculosis Drug-Induced Liver Injury.

Authors:  Yifan Bao; Xiaochao Ma; Theodore P Rasmussen; Xiao-Bo Zhong
Journal:  Curr Pharmacol Rep       Date:  2018-03-15

7.  NAT2 Genotype and Isoniazid Medication in Children.

Authors:  Klaus Golka; Silvia Selinski
Journal:  EBioMedicine       Date:  2016-08-26       Impact factor: 8.143

8.  Investigating the CYP2E1 Potential Role in the Mechanisms Behind INH/LPS-Induced Hepatotoxicity.

Authors:  Hozeifa M Hassan; Bashir A Yousef; Hongli Guo; Liu Xiaoxin; Luyong Zhang; Zhenzhou Jiang
Journal:  Front Pharmacol       Date:  2018-03-07       Impact factor: 5.810

9.  Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq.

Authors:  Alice Limonciel; Gamze Ates; Giada Carta; Anja Wilmes; Manfred Watzele; Peter J Shepard; Harper C VanSteenhouse; Bruce Seligmann; Joanne M Yeakley; Bob van de Water; Mathieu Vinken; Paul Jennings
Journal:  Arch Toxicol       Date:  2018-07-14       Impact factor: 5.153

10.  Elevated CPK levels after hydrazine inhalation exposure in an F16 aircraft technician.

Authors:  Yair Binyamin; Amit Frenkel; Evgeni Brotfain; Leonid Koyfman; Ori Shliom; Moti Klein
Journal:  Toxicol Rep       Date:  2018-09-10
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