Zhengxiao Li1,2, Lizhi Hu3, Peter M Elias2, Mao-Qiang Man2. 1. Department of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China. 2. Dermatology Service, Veterans Affairs Medical Center, and Department of Dermatology, University of California, San Francisco, CA, USA. 3. Key Laboratory of Immune Microenvironment and Disease (Ministry of State Education), Immunology Department, Tianjin Medical University, Tianjin, 300070, China.
Abstract
BACKGROUND: Sensitive skin is defined as a spectrum of unpleasant sensations in response to a variety of stimuli. However, only some skin care products provoke cutaneous symptoms in individuals with sensitive skin. Hence, it would be useful to identify products that could provoke cutaneous symptoms in individuals with sensitive skin. OBJECTIVE: To assess whether vehicles, as well as certain branded skin care products, can alter epidermal function following topical applications to normal mouse skin. METHODS: Following topical applications of individual vehicle or skin care product to C57BL/6J mice twice daily for 4 days, transepidermal water loss (TEWL) rates, stratum corneum (SC) hydration and skin surface pH were measured on treated versus untreated mouse skin with an MPA5 device and pH 900 pH meter. RESULTS: Our results show that all tested products induced abnormalities in epidermal functions of varying severity, including elevations in TEWL and skin surface pH, and reduced SC hydration. CONCLUSIONS: Our results suggest that mice can serve as a predictive model that could be used to evaluate the potential safety of skin care products in humans with sensitive skin.
BACKGROUND: Sensitive skin is defined as a spectrum of unpleasant sensations in response to a variety of stimuli. However, only some skin care products provoke cutaneous symptoms in individuals with sensitive skin. Hence, it would be useful to identify products that could provoke cutaneous symptoms in individuals with sensitive skin. OBJECTIVE: To assess whether vehicles, as well as certain branded skin care products, can alter epidermal function following topical applications to normal mouse skin. METHODS: Following topical applications of individual vehicle or skin care product to C57BL/6J mice twice daily for 4 days, transepidermal water loss (TEWL) rates, stratum corneum (SC) hydration and skin surface pH were measured on treated versus untreated mouse skin with an MPA5 device and pH 900 pH meter. RESULTS: Our results show that all tested products induced abnormalities in epidermal functions of varying severity, including elevations in TEWL and skin surface pH, and reduced SC hydration. CONCLUSIONS: Our results suggest that mice can serve as a predictive model that could be used to evaluate the potential safety of skin care products in humans with sensitive skin.
Authors: Li-Ning Huang; Yi-Ping Zhong; Dan Liu; Xiao-Hua Wang; Can-Yi Gong; Si Wen; Peter M Elias; Bin Yang; Mao-Qiang Man Journal: Contact Dermatitis Date: 2018-09-12 Impact factor: 6.600
Authors: Young Bin Lee; Sung Ku Ahn; Gun Young Ahn; Hana Bak; Seung Phil Hong; Eun Jung Go; Chang Ook Park; Sang Eun Lee; Weon Ju Lee; Hyun-Chang Ko; Jee-Bum Lee; Hyung Joo Kim; Kun Park; Sang-Hoon Lee; Dong Hoon Song; Sun Young Choi; Yeol Oh Sung; Tae-Hyun Kim; Ja Woong Goo Journal: Ann Dermatol Date: 2019-10-31 Impact factor: 1.444