Hans P Sathasivam1,2,3, Gareth R Davies1, Nicholas M Boyd1. 1. University of Western Australia, 35 Stirling Highway Crawley WA 6009, Perth, Australia. 2. Dental Department, Sultan Ismail Hospital, 81100 Johor Bahru, Malaysia. 3. School of Dental Sciences, Framlington Place, Newcastle University, Newcastle upon Tyne NE2 4BW.
Abstract
BACKGROUND: Osteoradionecrosis of the jaw (ORNJ) is a well-recognized complication of radiotherapy. The purpose of this study was to assess predictive factors for the development of ORNJ. METHODS: A retrospective study of 325 patients with head and neck squamous cell carcinoma (HNSCC) treated at one institution between January 1, 1999, and December 31, 2008, was conducted. Outcome measure was the presence/absence of ORNJ. Time to event was recorded and Cox proportional hazard regression analysis was used to determine statistically significant predictive factors. RESULTS: Fifty-nine patients had ORNJ. Statistical analysis using Cox regression analysis identified several statistically significant variables: dentoalveolar surgery; peri-resective surgery of the jaw; continued tobacco usage after radiotherapy, diabetes mellitus type 2 (DM2); and total radiation dose. CONCLUSION: Patients at greater risk of developing ORNJ can be identified and measures can be instituted to reduce its incidence and expedite management when it does occur.
BACKGROUND:Osteoradionecrosis of the jaw (ORNJ) is a well-recognized complication of radiotherapy. The purpose of this study was to assess predictive factors for the development of ORNJ. METHODS: A retrospective study of 325 patients with head and neck squamous cell carcinoma (HNSCC) treated at one institution between January 1, 1999, and December 31, 2008, was conducted. Outcome measure was the presence/absence of ORNJ. Time to event was recorded and Cox proportional hazard regression analysis was used to determine statistically significant predictive factors. RESULTS: Fifty-nine patients had ORNJ. Statistical analysis using Cox regression analysis identified several statistically significant variables: dentoalveolar surgery; peri-resective surgery of the jaw; continued tobacco usage after radiotherapy, diabetes mellitus type 2 (DM2); and total radiation dose. CONCLUSION:Patients at greater risk of developing ORNJ can be identified and measures can be instituted to reduce its incidence and expedite management when it does occur.
Authors: Suad Aljohani; Riham Fliefel; Teresa Franziska Brunner; Aristeidis Chronopoulos; Nada Binmadi; Sven Otto Journal: J Int Med Res Date: 2022-06 Impact factor: 1.573
Authors: John P Leonetti; Jeffrey R Weishaar; David Gannon; Grant A Harmon; Alec Block; Douglas E Anderson Journal: J Neurooncol Date: 2020-05-11 Impact factor: 4.130
Authors: Joonas Toivonen; Mikko Björkqvist; Heikki Minn; Pekka K Vallittu; Jami Rekola Journal: J Appl Clin Med Phys Date: 2019-11-29 Impact factor: 2.102