AIMS: This study aimed to examine the association between prenatal alcohol exposure and hearing impairment among Japanese children using early childhood health check-up data. METHODS: This retrospective cohort study used population-based health check-up data for children who were born between April 2000 and March 2013 in Hofu city, Japan. Logistic regression models were used to evaluate the association between prenatal alcohol exposure and hearing impairment among children at the age of 36 months. The models were adjusted for mother's age, smoking habit, child sex, birth weight, birth order, history of otitis media and familial history of hearing impairment. RESULTS: Among the 16,211 registered children, 10,680 children had maternal gestational information and underwent a health check-up at the age of 36 months. A total of 10,562 children were included in the analyses, which revealed that 640 children required a re-examination for hearing impairment, 157 children required a detailed examination for hearing impairment and 83 children were receiving treatment for hearing impairment at 36 months. Prenatal alcohol exposure was independently associated with suspected hearing impairment among children after adjusting for potential confounders. CONCLUSIONS: Our findings suggest that prenatal alcohol exposure may adversely affect the auditory system of children. SHORT SUMMARY: Prenatal alcohol exposure was associated with suspected hearing impairment among children at 36 months, based on the findings of a population-based retrospective cohort study that used health check-up data from 10,562 Japanese children.
AIMS: This study aimed to examine the association between prenatal alcohol exposure and hearing impairment among Japanese children using early childhood health check-up data. METHODS: This retrospective cohort study used population-based health check-up data for children who were born between April 2000 and March 2013 in Hofu city, Japan. Logistic regression models were used to evaluate the association between prenatal alcohol exposure and hearing impairment among children at the age of 36 months. The models were adjusted for mother's age, smoking habit, child sex, birth weight, birth order, history of otitis media and familial history of hearing impairment. RESULTS: Among the 16,211 registered children, 10,680 children had maternal gestational information and underwent a health check-up at the age of 36 months. A total of 10,562 children were included in the analyses, which revealed that 640 children required a re-examination for hearing impairment, 157 children required a detailed examination for hearing impairment and 83 children were receiving treatment for hearing impairment at 36 months. Prenatal alcohol exposure was independently associated with suspected hearing impairment among children after adjusting for potential confounders. CONCLUSIONS: Our findings suggest that prenatal alcohol exposure may adversely affect the auditory system of children. SHORT SUMMARY: Prenatal alcohol exposure was associated with suspected hearing impairment among children at 36 months, based on the findings of a population-based retrospective cohort study that used health check-up data from 10,562 Japanese children.
Authors: Abigail M Ernst; Blake A Gimbel; Erik de Water; Judith K Eckerle; Joshua P Radke; Michael K Georgieff; Jeffrey R Wozniak Journal: Nutrients Date: 2022-02-06 Impact factor: 5.717