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Literature DB >> 291443

[Multidrug chemotherapy of osteogenic sarcoma (author's transl)].

Abstract

Osteogenic sarcoma may be treated effectively by radical surgical removal of the primary tumor and combined chemotherapy, including Adriamycin and high dose Methotrexate. In order to render any protocol a safe procedure, strict precautions are required to avoid drug toxicity. We present a protocol, "COSS 77", presently employed in several university hospitals of West Germany and Austria. Final results concerning long term prognosis and long term side effects are not yet available.

Entities: Chemical Disease

Mesh：

Substances：
Doxorubicin
Methotrexate

Year: 1979 PMID： 291443 DOI： 10.1007/bf01013224

Source DB: PubMed Journal: Blut ISSN： 0006-5242

39 in total

1. Multidrug chemotherapy in pulmonary treatment of osteosarcoma.

Authors: W W Sutow; E A Gehan; T J Vietti; A E Frias; P G Dyment
Journal: J Bone Joint Surg Am Date: 1976-07 Impact factor: 5.284

2. Tissue pharmacokinetics, inhibition of DNA synthesis and tumor cell kill after high-dose methotrexate in murine tumor models.

Authors: F M Sirotnak; R C Donsbach; D M Dorick; D M Moccio
Journal: Cancer Res Date: 1976-12 Impact factor: 12.701

3. Chemotherapy and thoractomy for metastatic osteogenic sarcoma. A model for adjuvant chemotherapy and the rationale for the timing of thoracic surgery.

Authors: G Rosen; A G Huvos; C Mosende; E J Beattie; P R Exelby; B Capparos; R C Marcove
Journal: Cancer Date: 1978-03 Impact factor: 6.860

4. The effects of antibiotics and cancer chemotherapeutic agents on the cellular transport and antitumor activity of methotrexate in L1210 murine leukemia.

Authors: R F Zager; S A Frisby; V T Oliverio
Journal: Cancer Res Date: 1973-07 Impact factor: 12.701

[Multidrug chemotherapy of osteogenic sarcoma (author's transl)].

1. Multidrug chemotherapy in pulmonary treatment of osteosarcoma.

2. Tissue pharmacokinetics, inhibition of DNA synthesis and tumor cell kill after high-dose methotrexate in murine tumor models.

3. Chemotherapy and thoractomy for metastatic osteogenic sarcoma. A model for adjuvant chemotherapy and the rationale for the timing of thoracic surgery.

4. The effects of antibiotics and cancer chemotherapeutic agents on the cellular transport and antitumor activity of methotrexate in L1210 murine leukemia.

5. Massive preoperative radiation therapy in the treatment of osteogenic sarcoma.

6. Incidence of drug-related deaths secondary to high-dose methotrexate and citrovorum factor administration.

7. Degradation and clearance of methotrexate in children with osteosarcoma receiving high-dose infusion.

8. Concepts for systemic treatment of micrometastases.

9. Adjuvant treatment of osteogenic sarcoma with high-dose cyclophosphamide.

10. [Suppression of cytostatic effect of amethopterin (methotrexate) with methyltetrahydrofolic acid].

1. Osteosarcoma: improvement in survival limited to high-grade patients only.