Literature DB >> 29143065

[Complex joint reconstruction and joint transplantation with the FLOCSAT concept-planning and surgical implementation].

C Krettek1, J-D Clausen2, C Neunaber3.   

Abstract

Cartilage defects in adult patients are so far incurable. Fresh osteochondral allograft (OCA) transplantation is based on the insertion of mature, living, mechanically sound hyaline cartilage into an osteochondral defect where it undergoes osseointegration. Intact hyaline cartilage of OCA does not cause immune reactions in the recipient. Many reports show that small OCA have good osseointegration and show good long-term results. These observations have been incorporated into the development of the fresh large (> 10 cm2) osteochondral shell allograft transplantation (FLOCSAT) concept, which is based on the following principles: 1) the thickness of the osseous layer should be kept as thin as possible (target < 6-8 mm) so that the transplant remains stable and fixable. This results in reduced segments of vascularization, simplified ossification and reduced immunogenic bone volume. 2) The bone surface is processed and enlarged (oscillating saw: pie crust technique, drill holes) and areas of sclerosis are simultaneously broken off. 3) Cell reduction and washing out of the bony layer with a pulsatile jet lavage. 4) Prevention of impaction and dessication: cartilage with its living chondrocytes are very sensitive to mechanical contusion and dessication. When introducing the transplant, the tissue must therefore be continually moistened and the pressure acting on the cartilage must be controlled. 5) Stable fixation: extensive uniplanar osteochondral transplants cannot be inserted by the press-fit method; therefore, fixation is carried out with small implants. In this publication we demonstrate how severe and complex posttraumatic or degenerative delayed problems can be solved using FLOCSAT.

Entities:  

Keywords:  Cartilage therapy; FLOCSAT; Fresh osteochondral allograft; Joint destruction; Joint transplantation

Mesh:

Year:  2017        PMID: 29143065     DOI: 10.1007/s00113-017-0429-8

Source DB:  PubMed          Journal:  Unfallchirurg        ISSN: 0177-5537            Impact factor:   1.000


  22 in total

1.  Meniscal transplantation in symptomatic patients less than fifty years old.

Authors:  Frank R Noyes; Sue D Barber-Westin; Marc Rankin
Journal:  J Bone Joint Surg Am       Date:  2004-07       Impact factor: 5.284

2.  Management of acute rejection 2 years after allogeneic vascularized knee joint transplantation.

Authors:  M Diefenbeck; F Wagner; M H Kirschner; A Nerlich; T Mückley; G O Hofmann
Journal:  Transpl Int       Date:  2006-07       Impact factor: 3.782

3.  You can do arthroplasty in a young patient, but...: Commentary on articles by John P. Meehan, MD, et al.: "Younger age is associated with a higher risk of early periprosthetic joint infection and aseptic mechanical failure after total knee arthroplasty," and Vinay K. Aggarwal, et al.: "Revision total knee arthroplasty in the young patient: is there trouble on the horizon?".

Authors:  Kelly G Vince
Journal:  J Bone Joint Surg Am       Date:  2014-04-02       Impact factor: 5.284

4.  A prospective randomized clinical study of mosaic osteochondral autologous transplantation versus microfracture for the treatment of osteochondral defects in the knee joint in young athletes.

Authors:  Rimtautas Gudas; Romas J Kalesinskas; Vytautas Kimtys; Edgaras Stankevicius; Vytautas Toliusis; Giedrius Bernotavicius; Alfredas Smailys
Journal:  Arthroscopy       Date:  2005-09       Impact factor: 4.772

5.  Long-term followup of the use of fresh osteochondral allografts for posttraumatic knee defects.

Authors:  Allan E Gross; Nadav Shasha; Phil Aubin
Journal:  Clin Orthop Relat Res       Date:  2005-06       Impact factor: 4.176

6.  Effect of impact on chondrocyte viability during insertion of human osteochondral grafts.

Authors:  Boris H Borazjani; Albert C Chen; Won C Bae; Shantanu Patil; Robert L Sah; Gary S Firestein; William D Bugbee
Journal:  J Bone Joint Surg Am       Date:  2006-09       Impact factor: 5.284

Review 7.  Autologous chondrocyte implantation: a systematic review.

Authors:  Joshua D Harris; Robert A Siston; Xueliang Pan; David C Flanigan
Journal:  J Bone Joint Surg Am       Date:  2010-09-15       Impact factor: 5.284

Review 8.  Allografts in articular cartilage repair.

Authors:  Simon Görtz; William D Bugbee
Journal:  Instr Course Lect       Date:  2007

9.  Failures in bipolar fresh osteochondral allograft for the treatment of end-stage knee osteoarthritis.

Authors:  S Giannini; R Buda; A Ruffilli; G Pagliazzi; A Ensini; B Grigolo; G Desando; F Vannini
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2014-04-04       Impact factor: 4.342

Review 10.  Articular Cartilage Injury and Potential Remedies.

Authors:  Susanna Chubinskaya; Dominik Haudenschild; Seth Gasser; James Stannard; Christian Krettek; Joseph Borrelli
Journal:  J Orthop Trauma       Date:  2015-12       Impact factor: 2.512

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.