José A García Lavandeira1,2, Alberto Ruano-Ravina2,3,4, Karl T Kelsey4, María Torres-Durán5, Isaura Parente-Lamelas6, Virginia Leiro-Fernández5, Maruxa Zapata2, José Abal-Arca6, Iria Vidal-García7, Carmen Montero-Martínez7, Margarita Amenedo8, Olalla Castro-Añón9, Antonio Golpe-Gómez10, Rosirys Guzmán-Taveras11, Cristina Martínez11, Mariano Provencio12, María J Mejuto-Martí13, Silvia García-García14, Alberto Fernández-Villar5, María Piñeiro3, Juan M Barros-Dios2,3,15. 1. Admission and Documentation Service, University Hospital Complex of a Coruña, Spain. 2. Department of Preventive Medicine and Public Health, University of Santiago de Compostela, Spain. 3. CIBER de Epidemiología y Salud Pública, CIBERESP, Spain. 4. Department of Epidemiology, Brown School of Public Health, Brown University, Providence, Rhode Island, USA. 5. Service of Neumology, University Hospital Complex of Vigo, Vigo, Spain. 6. Service of Neumology, Ourense Hospital Complex, Ourense, Spain. 7. Service of Neumology, University Hospital Complex of A Coruña, Coruña, Spain. 8. Oncologic Hospital, A Coruna, Spain. 9. Service of Neumology, Hospital Lucus Augusti, Lugo, Spain. 10. Service of Neumology, Santiago de Compostela University Clinic Hospital, Santiago de Compostela, Spain. 11. National Institute of Silicosis, University Hospital of Asturias, Asturias, Oviedo, Spain. 12. Service of Oncology, Puerta de Hierro University Hospital, Madrid, Spain. 13. Service of Neumology, Hospital Arquitecto Marcide, Ferrol, Spain. 14. Service of Neumology. Hospital Complex of León, León, Spain. 15. Service of Preventive Medicine, University Hospital Complex of Santiago de Compostela, Spain.
Abstract
Background: Lung cancer is the deadliest cancer in developed countries but the etiology of lung cancer risk in never smokers (LCRINS) is largely unknown. We aim to assess the effects of alcohol consumption, in its different forms, on LCRINS. Methods: We pooled six multi-center case-control studies developed in the northwest of Spain. Cases and controls groups were composed of never smokers. We selected incident cases with anatomopathologically confirmed lung cancer diagnoses. All participants were personally interviewed. We performed two groups of statistical models, applying unconditional logistic regression with generalized additive models. One considered the effect of alcohol type consumption and the other considered the quantity of each alcoholic beverage consumed. Results: A total of 438 cases and 863 controls were included. Median age was 71 and 66, years, respectively. Adenocarcinoma was the predominant histological type, comprising 66% of all cases. We found that any type of wine consumption posed an OR of 2.20 OR 95%CI 1.12-4.35), and spirits consumption had an OR of 1.90 (95%CI 1.13-3.23). Beer consumption had an OR of 1.33 (95%CI 0.82-2.14). These results were similar when women were analyzed separately, but for men there was no apparent risk for any alcoholic beverage. The dose-response analysis for each alcoholic beverage revealed no clear pattern. Conclusions: Wine and spirits consumption might increase the risk of LCRINSs, particularly in females. These results have to be taken with caution given the limitations of the present study.
Background: Lung cancer is the deadliest cancer in developed countries but the etiology of lung cancer risk in never smokers (LCRINS) is largely unknown. We aim to assess the effects of alcohol consumption, in its different forms, on LCRINS. Methods: We pooled six multi-center case-control studies developed in the northwest of Spain. Cases and controls groups were composed of never smokers. We selected incident cases with anatomopathologically confirmed lung cancer diagnoses. All participants were personally interviewed. We performed two groups of statistical models, applying unconditional logistic regression with generalized additive models. One considered the effect of alcohol type consumption and the other considered the quantity of each alcoholic beverage consumed. Results: A total of 438 cases and 863 controls were included. Median age was 71 and 66, years, respectively. Adenocarcinoma was the predominant histological type, comprising 66% of all cases. We found that any type of wine consumption posed an OR of 2.20 OR 95%CI 1.12-4.35), and spirits consumption had an OR of 1.90 (95%CI 1.13-3.23). Beer consumption had an OR of 1.33 (95%CI 0.82-2.14). These results were similar when women were analyzed separately, but for men there was no apparent risk for any alcoholic beverage. The dose-response analysis for each alcoholic beverage revealed no clear pattern. Conclusions: Wine and spirits consumption might increase the risk of LCRINSs, particularly in females. These results have to be taken with caution given the limitations of the present study.
Authors: Tiffany R Sanchez; Yaa Asantewaa Kafui Klu; Jeanine M Genkinger; James V Lacey; Nadia T Chung; Ana Navas-Acien Journal: Cancer Causes Control Date: 2020-09-24 Impact factor: 2.506