Limy Wong1, Aileen Counihan2, Patrick O'Kelly3, Donal J Sexton3, Conall M O'Seaghdha3, Colm Magee3,4, Dilly Little2, Peter J Conlon3,4. 1. Department of Nephrology and Transplantation, Beaumont Hospital, Dublin 9, Ireland. limywong@gmail.com. 2. Department of Transplantation and Urology, Beaumont Hospital, Dublin, Ireland. 3. Department of Nephrology and Transplantation, Beaumont Hospital, Dublin 9, Ireland. 4. Royal College of Surgeons in Ireland, Dublin, Ireland.
Abstract
BACKGROUND: Donor/recipient size mismatching and correlation to allograft outcome remains poorly defined. This study assessed the impact of donor body weight (DBW) to recipient body weight (RBW) ratio on allograft function and survival. METHODS: A total of 898 deceased donor renal transplant recipients were included in the study. Patients were divided into quartiles depending on the ratio of DBW/RBW: Q1 (≤ 0.88), Q2 (0.89-1.00), Q3 (1.01-1.22) and Q4 (> 1.22). Donor and recipient characteristics were obtained from the national kidney transplant service database. Serum creatinine and estimated glomerular filtration rate (eGFR) at 1 and 5 years after transplant were compared. RESULTS: Q4 patients had a higher eGFR 1 year post-transplant (median 59.5 ml/min, IQR 46.8-76.2) compared to Q1-Q3 which had median eGFRs of 54.3, 54.8 and 55.3 ml/min, respectively (p < 0.001). At 5 years post-transplant, there were modest differences in the eGFR across the four quartiles, Q1-4 with median eGFRs of 56.9, 61.1, 61.2 and 58.6 ml/min, respectively (p = 0.02). However, there were no significant differences in 1- and 5-year allograft survival between groups. CONCLUSIONS: In the setting of deceased donor renal transplantation, mismatching of donor to recipient weight had no impact on 5-year allograft survival, but a low DBW/RBW ratio is modestly associated with lower eGFR.
BACKGROUND:Donor/recipient size mismatching and correlation to allograft outcome remains poorly defined. This study assessed the impact of donor body weight (DBW) to recipient body weight (RBW) ratio on allograft function and survival. METHODS: A total of 898 deceased donor renal transplant recipients were included in the study. Patients were divided into quartiles depending on the ratio of DBW/RBW: Q1 (≤ 0.88), Q2 (0.89-1.00), Q3 (1.01-1.22) and Q4 (> 1.22). Donor and recipient characteristics were obtained from the national kidney transplant service database. Serum creatinine and estimated glomerular filtration rate (eGFR) at 1 and 5 years after transplant were compared. RESULTS: Q4 patients had a higher eGFR 1 year post-transplant (median 59.5 ml/min, IQR 46.8-76.2) compared to Q1-Q3 which had median eGFRs of 54.3, 54.8 and 55.3 ml/min, respectively (p < 0.001). At 5 years post-transplant, there were modest differences in the eGFR across the four quartiles, Q1-4 with median eGFRs of 56.9, 61.1, 61.2 and 58.6 ml/min, respectively (p = 0.02). However, there were no significant differences in 1- and 5-year allograft survival between groups. CONCLUSIONS: In the setting of deceased donor renal transplantation, mismatching of donor to recipient weight had no impact on 5-year allograft survival, but a low DBW/RBW ratio is modestly associated with lower eGFR.
Authors: A J Matas; J M Smith; M A Skeans; B Thompson; S K Gustafson; D E Stewart; W S Cherikh; J L Wainright; G Boyle; J J Snyder; A K Israni; B L Kasiske Journal: Am J Transplant Date: 2015-01 Impact factor: 8.086
Authors: Abdalla Elbadri; Carol Traynor; John T Veitch; Patrick O'Kelly; Colm Magee; Mark Denton; Conall O'Sheaghdha; Peter J Conlon Journal: Ren Fail Date: 2015-01-14 Impact factor: 2.606
Authors: Jennifer McGee; Jeanette H Magnus; Tareq M Islam; Bernard M Jaffe; Rubin Zhang; Sander S Florman; L Lee Hamm; Navyata Mruthinti; Karen Sullivan; Douglas P Slakey Journal: J Am Coll Surg Date: 2010-05 Impact factor: 6.113
Authors: E D Poggio; S Hila; B Stephany; R Fatica; V Krishnamurthi; C del Bosque; D Goldfarb; B Herts; V W Dennis; P S Heeger; W Braun Journal: Am J Transplant Date: 2006-03 Impact factor: 8.086