| Literature DB >> 29137975 |
D Lin1, Y Liang1, X Jing1, Y Chen1, M Lei1, Z Zeng1, T Zhou1, X Wu1, S Peng1, D Zheng1, K Huang1, L Yang1, S Xiao1, J Liu1, E Tao2.
Abstract
Long non-coding RNAs (lncRNAs) are a new research focus that are reported to influence the pathogenetic process of neurodegenerative disorders. To uncover new disease-associated genes and their relevant mechanisms, we carried out a gene microarray analysis based on a Parkinson's disease (PD) in vitro model induced by α-synuclein oligomers. This cellular model induced by 25 μmol/L α-synuclein oligomers has been confirmed to show the stable, transmissible neurotoxicity of α-synuclein, a typical PD pathological marker. And several differentially expressed lncRNAs and mRNAs were identified in this model, such as G046036, G030771, AC009365.4, RPS14P3, CTB-11I22.1, and G007549. Subsequent ceRNA analysis determined the potential relationships between these lncRNAs and their associated mRNAs and microRNAs. The results of the present study widen our horizon of PD susceptibility genes and provide new pathways towards efficient diagnostic biomarkers and therapeutic targets for PD.Entities:
Keywords: Long non-coding RNA; Microarray analysis; Parkinson’s disease; α-Synuclein oligomer
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Year: 2017 PMID： 29137975 DOI： 10.1016/j.brainres.2017.11.007
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252