Baozhu Wei1, Yang Liu2, Xuan Lin2, Ying Fang2, Jing Cui2, Jing Wan3. 1. Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China. 2. Department of Endocrinology, China Resources and WISCO General Hospital, Wuhan, China. 3. Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China. Electronic address: wanjing2017@163.com.
Abstract
BACKGROUND & AIMS: Epidemiological studies show inconsistent findings on the association of dietary fiber intake with risk of metabolic syndrome (MetS). Herein, we aim to conduct a meta-analysis of published studies to determine the role of dietary fiber in prevention of MetS. METHODS: A systematical search in PubMed and Embase databases through December 2016, together with reference scrutiny of relevant literature, was performed to identify studies for inclusion. We aggregated the odds ratios (ORs) with 95% confidence intervals (CIs) of MetS using a random effect model. Dose-response relationship between fiber intake and MetS was also evaluated. RESULTS: This meta-analysis included 8 cross-sectional and 3 cohort studies, totaling 28,241 participants and 9140 MetS cases. The highest versus lowest fiber intake was associated with a reduced risk of MetS (OR: 0.85, 95% CI: 0.79-0.92; P = 0.005), with moderate heterogeneity (I2 = 64%, P = 0.001) across studies. The benefit of fiber intake was significant among cross-sectional studies (OR: 0.85, 95% CI: 0.78-0.92; P < 0.001) but not among cohort studies (OR: 0.86, 95% CI: 0.70-1.06; P = 0.16). In dose-response analysis, we found a curvilinear relationship between fiber consumption and prevalence of MetS. Compared with non-fiber intake, the ORs (95% CIs) of MetS across fiber intake levels were 0.85 (0.79-0.91), 0.76 (0.67-0.85), 0.73 (0.65-0.83), and 0.73 (0.65-0.82) for 10, 20, 30, and 40 g/d, respectively. CONCLUSIONS: Dietary fiber intake is associated with less likelihood of having MetS. Additional large, prospective studies are warranted to enhance our findings.
BACKGROUND & AIMS: Epidemiological studies show inconsistent findings on the association of dietary fiber intake with risk of metabolic syndrome (MetS). Herein, we aim to conduct a meta-analysis of published studies to determine the role of dietary fiber in prevention of MetS. METHODS: A systematical search in PubMed and Embase databases through December 2016, together with reference scrutiny of relevant literature, was performed to identify studies for inclusion. We aggregated the odds ratios (ORs) with 95% confidence intervals (CIs) of MetS using a random effect model. Dose-response relationship between fiber intake and MetS was also evaluated. RESULTS: This meta-analysis included 8 cross-sectional and 3 cohort studies, totaling 28,241 participants and 9140 MetS cases. The highest versus lowest fiber intake was associated with a reduced risk of MetS (OR: 0.85, 95% CI: 0.79-0.92; P = 0.005), with moderate heterogeneity (I2 = 64%, P = 0.001) across studies. The benefit of fiber intake was significant among cross-sectional studies (OR: 0.85, 95% CI: 0.78-0.92; P < 0.001) but not among cohort studies (OR: 0.86, 95% CI: 0.70-1.06; P = 0.16). In dose-response analysis, we found a curvilinear relationship between fiber consumption and prevalence of MetS. Compared with non-fiber intake, the ORs (95% CIs) of MetS across fiber intake levels were 0.85 (0.79-0.91), 0.76 (0.67-0.85), 0.73 (0.65-0.83), and 0.73 (0.65-0.82) for 10, 20, 30, and 40 g/d, respectively. CONCLUSIONS: Dietary fiber intake is associated with less likelihood of having MetS. Additional large, prospective studies are warranted to enhance our findings.
Authors: Jea Woo Kang; Xinyu Tang; Charles J Walton; Mark J Brown; Rachel A Brewer; Rolando L Maddela; Jack Jingyuan Zheng; Joanne K Agus; Angela M Zivkovic Journal: Front Nutr Date: 2022-06-17
Authors: Sofia M Murga-Garrido; Qilin Hong; Tzu-Wen L Cross; Evan R Hutchison; Jessica Han; Sydney P Thomas; Eugenio I Vivas; John Denu; Danilo G Ceschin; Zheng-Zheng Tang; Federico E Rey Journal: Microbiome Date: 2021-05-20 Impact factor: 14.650