| Literature DB >> 29136957 |
Jun Li1, Zhiyuan Tang2, Haiying Wang2, Wei Wu3, Fengqiu Zhou2, Honggang Ke4, Wei Lu5, Shu Zhang6, Yanju Zhang2, Si Yang2, Songshi Ni2, Jianan Huang7.
Abstract
Chemokine plays an important role in lung cancer and CXCL6 is one of chemokine, however, its effect on miRNAs profile and its roles in non-small cell lung cancer cell (NSCLC) is not elucidated. This study is purposed to explore the influence of CXCL6 on miRNA expression profile and found that CXCL6 could reduce the expression of miR-515-5p in NSCLC cells. MiR-515-5p in NSCLC cells could inhibit NSCLC survival and metastasis. MiR-515-5p acted as a tumor suppressor by targeting CXCL6 in NSCLC cells. These data highlighted a novel molecular interaction between miR-515-5p and CXCL6. MiR-515-5p may constitute a potential therapy target for NSCLC.Entities:
Keywords: CXCL6; Metastasis; NSCLC; miR-515-5p
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Year: 2017 PMID： 29136957 DOI： 10.1016/j.biopha.2017.11.004
Source DB: PubMed Journal: Biomed Pharmacother ISSN： 0753-3322 Impact factor: 6.529