Maria Isabel Fuhro1, Gilson P Dorneles2, Francini P Andrade3, Pedro R T Romão4, Alessandra Peres1,4, Mariane B Monteiro5. 1. Research Center, Methodist University Center IPA, Porto Alegre, Brazil. 2. Graduate Program in Health Sciences, Laboratory of Cellular and Molecular Immunology, Federal University of Health Sciences of Porto Alegre (UFCSPA), Rua Sarmento Leite, 245. Lab 803 (Prédio 3), Porto Alegre, RS, CEP 90050-170, Brazil. gilsonpd@hotmail.com. 3. Federal University of Rio Grande do Sul, Porto Alegre, Brazil. 4. Graduate Program in Health Sciences, Laboratory of Cellular and Molecular Immunology, Federal University of Health Sciences of Porto Alegre (UFCSPA), Rua Sarmento Leite, 245. Lab 803 (Prédio 3), Porto Alegre, RS, CEP 90050-170, Brazil. 5. Physical Therapy Department, Federal University of Health Sciences of Porto Alegre (UFCSPA), Rua Sarmento Leite, 245. Lab 803 (Prédio 3), Porto Alegre, RS, CEP 90050-170, Brazil. marianemonteiro@hotmail.com.
Abstract
PURPOSE: To evaluate the acute response of natural killer (NK) cell subsets of chronic kidney disease patients submitted tointradialytic exercise in a randomized crossover study. METHODS: Nine patients were submitted to a single bout of 20-min intradialytic exercise and a control hemodialysis (HD) session with an interval of 7 days between them. Peripheral blood sample was collected at baseline, during HD and immediately after HD in each trial to evaluate the peripheral frequency of NK cells and their subsets (CD3-CD56bright and CD3-CD56dim), systemic cortisol concentrations, C-reactive protein (CRP), creatine kinase activity (CK), and urea and creatinine levels. RESULTS: HD therapy induced a significant decrease in NK cells frequency (p = 0.039), NK CD3-CD56bright cells (p = 0.04), and CD3-CD56dim cells (p = 0.036). On the other hand, no significant alterations were observed in NK cells and NK subsets during and after intradialytic exercise trial (p > 0.05). Neither trial altered CRP levels or serum CK activity during and after HD therapy (p > 0.05). However, HD therapy increased cortisol concentrations after HD therapy (p = 0.034). CONCLUSIONS: This study suggests the potential role of intradialytic exercise to prevent the decrease in peripheral frequency of NK cell subsets during HD therapy. Moreover, moderate intensity intradialytic exercise did not exacerbate the systemic inflammation or induce muscle damage during HD therapy.
RCT Entities:
PURPOSE: To evaluate the acute response of natural killer (NK) cell subsets of chronic kidney diseasepatients submitted to intradialytic exercise in a randomized crossover study. METHODS: Nine patients were submitted to a single bout of 20-min intradialytic exercise and a control hemodialysis (HD) session with an interval of 7 days between them. Peripheral blood sample was collected at baseline, during HD and immediately after HD in each trial to evaluate the peripheral frequency of NK cells and their subsets (CD3-CD56bright and CD3-CD56dim), systemic cortisol concentrations, C-reactive protein (CRP), creatine kinase activity (CK), and urea and creatinine levels. RESULTS:HD therapy induced a significant decrease in NK cells frequency (p = 0.039), NK CD3-CD56bright cells (p = 0.04), and CD3-CD56dim cells (p = 0.036). On the other hand, no significant alterations were observed in NK cells and NK subsets during and after intradialytic exercise trial (p > 0.05). Neither trial altered CRP levels or serum CK activity during and after HD therapy (p > 0.05). However, HD therapy increased cortisol concentrations after HD therapy (p = 0.034). CONCLUSIONS: This study suggests the potential role of intradialytic exercise to prevent the decrease in peripheral frequency of NK cell subsets during HD therapy. Moreover, moderate intensity intradialytic exercise did not exacerbate the systemic inflammation or induce muscle damage during HD therapy.
Entities:
Keywords:
Exercise; Hemodialysis; Immune response; Inflammation; NK cells
Authors: Philipp Zimmer; Alexander Schenk; Markus Kieven; Michelle Holthaus; Jonas Lehmann; Lukas Lövenich; Wilhelm Bloch Journal: Exerc Immunol Rev Date: 2017 Impact factor: 6.308
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