Alessandra Peres1,2, Daniela Lazzarotto Perotto1, Gilson Pires Dorneles1,2, Maria Isabel Severini Fuhro1, Mariane Borba Monteiro1,3. 1. a Research Center, Centro Universitário Metodista IPA , Porto Alegre , Brazil . 2. b Departmento de Ciências Básicas da Saúde , Universidade Federal de Ciências da Saúde de Porto Alegre , Porto Alegre , Brazil , and. 3. c Departmento de Fisioterapia , Universidade Federal de Ciências da Saúde de Porto Alegre , Porto Alegre , Brazil.
Abstract
BACKGROUND: Immunological dysfunctions and a pro-inflammatory environment are associated with higher risk of cardiovascular diseases in chronic kidney disease (CKD). Physical exercise can be an important anti-inflammatory strategy, but the effects in CKD remain poorly investigated. OBJECTIVE: Evaluate the acute inflammatory response to intradialytic exercise in the peripheral blood of individuals with CKD. METHODS: Nine patients, of both genders, with CKD and allocated in the ambulatory of hemodialysis of Hospital Ernesto Dornelles (Brazil), performed two sessions of hemodialysis (HD) in random form: aerobic intradialytic exercise sessions (EX, 20 min of moderate exercise in cycle-ergometer) and a control hemodialysis session (CON). Peripheral blood collection was made at the baseline, during and immediately after HD to evaluate the cytokine profile: interleukin-6, interleukin-10 (IL-10), interleukin-17a (IL-17a), interferon-gamma (INF-γ) and tumoral necrosis factor-alpha (TNF-α). RESULTS: INF-γ decreased during HD when compared with the pre moment in both sessions, while an increase in post HD was only found in the CON session. IL-17 was higher in post when compared with during HD in both sessions. In addition to the time effect, IL-10 presented a time × group interaction and the relative changes were significantly higher in EX when compared with the CON session. The relative changes in TNF-α tended to be higher in CON when compared with EX immediately post HD session. CONCLUSIONS: These data indicate that 20 min of intradialytic exercise have modest effect in systemic inflammation. However, the significant increase in IL-10 may indicate an immunoregulatory effect of physical exercise.
BACKGROUND: Immunological dysfunctions and a pro-inflammatory environment are associated with higher risk of cardiovascular diseases in chronic kidney disease (CKD). Physical exercise can be an important anti-inflammatory strategy, but the effects in CKD remain poorly investigated. OBJECTIVE: Evaluate the acute inflammatory response to intradialytic exercise in the peripheral blood of individuals with CKD. METHODS: Nine patients, of both genders, with CKD and allocated in the ambulatory of hemodialysis of Hospital Ernesto Dornelles (Brazil), performed two sessions of hemodialysis (HD) in random form: aerobic intradialytic exercise sessions (EX, 20 min of moderate exercise in cycle-ergometer) and a control hemodialysis session (CON). Peripheral blood collection was made at the baseline, during and immediately after HD to evaluate the cytokine profile: interleukin-6, interleukin-10 (IL-10), interleukin-17a (IL-17a), interferon-gamma (INF-γ) and tumoral necrosis factor-alpha (TNF-α). RESULTS: INF-γ decreased during HD when compared with the pre moment in both sessions, while an increase in post HD was only found in the CON session. IL-17 was higher in post when compared with during HD in both sessions. In addition to the time effect, IL-10 presented a time × group interaction and the relative changes were significantly higher in EX when compared with the CON session. The relative changes in TNF-α tended to be higher in CON when compared with EX immediately post HD session. CONCLUSIONS: These data indicate that 20 min of intradialytic exercise have modest effect in systemic inflammation. However, the significant increase in IL-10 may indicate an immunoregulatory effect of physical exercise.
Authors: Maria Isabel Fuhro; Gilson P Dorneles; Francini P Andrade; Pedro R T Romão; Alessandra Peres; Mariane B Monteiro Journal: Int Urol Nephrol Date: 2017-11-13 Impact factor: 2.370
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