Apple G Long1, Emma T Lundsmith2, Kathryn E Hamilton1. 1. Division of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA. 2. Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA.
Abstract
Colorectal cancer (CRC) is the fourth most common cancer in both men and women in the United States, resulting in over 55,000 deaths annually. Environmental and genetic factors influence the development of CRC, and inflammation is a critical hallmark of cancer that may arise from a variety of factors. PURPOSE OF REVIEW: While patients with inflammatory bowel disease (IBD) have a higher risk of developing CRC, sporadic CRCs may engender or be potentiated by inflammation as well. In this review, we focus on recent advances in basic and translational research utilizing murine models to understand the contribution of inflammatory signaling pathways to CRC. RECENT FINDINGS: We discuss advances in the utility of three-dimensional enteroid/colonoid/tumoroid cultures to understand immune-epithelial interactions in CRC, as well as the potential for utilizing patient-derived tumoroids for personalized therapies. SUMMARY: This review underscores the importance of understanding the complex molecular mechanisms underlying inflammation in sporadic CRC and highlights up-and-coming or new avenues for CRC biomarkers or therapies.
Colorectal cancer (CRC) is the fourth most common cancer in both men and women in the United States, resulting in over 55,000 deaths annually. Environmental and genetic factors influence the development of CRC, and inflammation is a critical hallmark of cancer that may arise from a variety of factors. PURPOSE OF REVIEW: While patients with inflammatory bowel disease (IBD) have a higher risk of developing CRC, sporadic CRCs may engender or be potentiated by inflammation as well. In this review, we focus on recent advances in basic and translational research utilizing murine models to understand the contribution of inflammatory signaling pathways to CRC. RECENT FINDINGS: We discuss advances in the utility of three-dimensional enteroid/colonoid/tumoroid cultures to understand immune-epithelial interactions in CRC, as well as the potential for utilizing patient-derived tumoroids for personalized therapies. SUMMARY: This review underscores the importance of understanding the complex molecular mechanisms underlying inflammation in sporadic CRC and highlights up-and-coming or new avenues for CRC biomarkers or therapies.
Authors: Nichole R Blatner; Mary F Mulcahy; Kristen L Dennis; Denise Scholtens; David J Bentrem; Joseph D Phillips; Soo Ham; Barry P Sandall; Mohammad W Khan; David M Mahvi; Amy L Halverson; Steven J Stryker; Anne-Marie Boller; Ashima Singal; Rebekka K Sneed; Bara Sarraj; Mohammed Javeed Ansari; Martin Oft; Yoichiro Iwakura; Liang Zhou; Andreas Bonertz; Philipp Beckhove; Fotini Gounari; Khashayarsha Khazaie Journal: Sci Transl Med Date: 2012-12-12 Impact factor: 17.956
Authors: Arianna Nenci; Christoph Becker; Andy Wullaert; Ralph Gareus; Geert van Loo; Silvio Danese; Marion Huth; Alexei Nikolaev; Clemens Neufert; Blair Madison; Deborah Gumucio; Markus F Neurath; Manolis Pasparakis Journal: Nature Date: 2007-03-14 Impact factor: 49.962
Authors: Cornelia Richter; Martina Herrero San Juan; Benno Weigmann; Dominik Bergis; Katrin Dauber; Michael H Muders; Gustavo B Baretton; Josef Martin Pfeilschifter; Halvard Bonig; Sebastian Brenner; Heinfried H Radeke Journal: Front Immunol Date: 2017-01-27 Impact factor: 7.561
Authors: Timon E Adolph; Michal F Tomczak; Lukas Niederreiter; Hyun-Jeong Ko; Janne Böck; Eduardo Martinez-Naves; Jonathan N Glickman; Markus Tschurtschenthaler; John Hartwig; Shuhei Hosomi; Magdalena B Flak; Jennifer L Cusick; Kenji Kohno; Takao Iwawaki; Susanne Billmann-Born; Tim Raine; Richa Bharti; Ralph Lucius; Mi-Na Kweon; Stefan J Marciniak; Augustine Choi; Susan J Hagen; Stefan Schreiber; Philip Rosenstiel; Arthur Kaser; Richard S Blumberg Journal: Nature Date: 2013-10-02 Impact factor: 49.962
Authors: Karl Katholnig; Birgit Schütz; Stephanie D Fritsch; David Schörghofer; Monika Linke; Nyamdelger Sukhbaatar; Julia M Matschinger; Daniela Unterleuthner; Martin Hirtl; Michaela Lang; Merima Herac; Andreas Spittler; Andreas Bergthaler; Gernot Schabbauer; Michael Bergmann; Helmut Dolznig; Markus Hengstschläger; Mark A Magnuson; Mario Mikula; Thomas Weichhart Journal: JCI Insight Date: 2019-10-17
Authors: Tatiana A Karakasheva; George A Dominguez; Ayumi Hashimoto; Eric W Lin; Christopher Chiu; Kate Sasser; Jae W Lee; Gregory L Beatty; Dmitry I Gabrilovich; Anil K Rustgi Journal: JCI Insight Date: 2018-03-22
Authors: Maha H Daghestani; Khushboo Ambreen; Hana H Hakami; Mohammed A Omair; Abdulaziz M Saleem; Nadia A Aleisa; Lina M AlNeghery; Mohannad H Amin; Hussah M Alobaid; Maha A Omair; Lena M Hassen Journal: Toxicol Res (Camb) Date: 2021-10-19 Impact factor: 2.680
Authors: Greta M de Waal; Willem J S de Villiers; Timothy Forgan; Timothy Roberts; Etheresia Pretorius Journal: Sci Rep Date: 2020-05-29 Impact factor: 4.379