Jesper Olsen1, Lene T Kirkeby2, Jørgen Olsen3, Susanne Eiholm4, Per Jess2, Ismail Gögenur5, Jesper T Troelsen6. 1. Department of Science, Systems and Models, Roskilde University, Roskilde, Denmark Department of Surgery, Roskilde University Hospital, Roskilde, Denmark josn@ruc.dk. 2. Department of Surgery, Roskilde University Hospital, Roskilde, Denmark. 3. Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen Denmark. 4. Department of Pathology, Roskilde University Hospital, Roskilde, Denmark. 5. Department of Surgery, Roskilde University Hospital, Roskilde, Denmark Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen Denmark. 6. Department of Science, Systems and Models, Roskilde University, Roskilde, Denmark.
Abstract
AIM: To investigate the expression of interleukin-6 (IL6) in colon cancer tissue, and to examine if the risk of relapse is influenced by IL6 expression. MATERIALS AND METHODS: Fresh-frozen biopsies from tumor and normal adjacent tissues were taken from patients with colon cancer during surgery and stored at -80 °C. mRNA expression for interleukin-6 was evaluated with reverse transcription real time quantitative polymerase chain reaction. Survival analyses were carried-out using a Cox competing risk regression model. RESULTS: IL6 mRNA was significantly more highly expressed in tumor tissue compared to normal adjacent tissue (p<0.001). We found no significant association with regard to IL6 expression and histological differentiation or cancer stage. We found a significant association between high IL6 expression and risk of relapse (Hazard Ratio=2.23, 95% CI=1.10-4.53; p<0.05), also when adjusted for clinicopathological characteristics (Hazard Ratio=2.16, 95% CI=1.07-4.40; p<0.05). CONCLUSION: Interleukin-6 is up-regulated in colon cancer tissue at the transcriptional level and is significantly associated with increased risk of relapse. Copyright
AIM: To investigate the expression of interleukin-6 (IL6) in colon cancer tissue, and to examine if the risk of relapse is influenced by IL6 expression. MATERIALS AND METHODS: Fresh-frozen biopsies from tumor and normal adjacent tissues were taken from patients with colon cancer during surgery and stored at -80 °C. mRNA expression for interleukin-6 was evaluated with reverse transcription real time quantitative polymerase chain reaction. Survival analyses were carried-out using a Cox competing risk regression model. RESULTS:IL6 mRNA was significantly more highly expressed in tumor tissue compared to normal adjacent tissue (p<0.001). We found no significant association with regard to IL6 expression and histological differentiation or cancer stage. We found a significant association between high IL6 expression and risk of relapse (Hazard Ratio=2.23, 95% CI=1.10-4.53; p<0.05), also when adjusted for clinicopathological characteristics (Hazard Ratio=2.16, 95% CI=1.07-4.40; p<0.05). CONCLUSION:Interleukin-6 is up-regulated in colon cancer tissue at the transcriptional level and is significantly associated with increased risk of relapse. Copyright
Authors: H Paul Redmond; Peter M Neary; Marcel Jinih; Emer O'Connell; Niamh Foley; Rolf W Pfirrmann; Jiang H Wang; D Peter O'Leary Journal: BMC Cancer Date: 2018-08-06 Impact factor: 4.430
Authors: Vittoria Disciglio; Andrea Devecchi; Orazio Palumbo; Massimo Carella; Donata Penso; Massimo Milione; Giorgio Valle; Marco Alessandro Pierotti; Marco Vitellaro; Lucio Bertario; Silvana Canevari; Stefano Signoroni; Loris De Cecco Journal: Chin J Cancer Date: 2016-06-07