OBJECTIVES: To evaluate the effect of physical activity levels on 10-year diabetes incidence and investigate the potential mechanism. METHODS: In 2001-2002, a random sample of apparently healthy 3042 men and women (18-89 years) was selected to participate in the ATTICA study. Several socio-demographic, clinical and lifestyle characteristics were recorded. Physical activity level was recorded through a translated, validated, version of International Physical Activity Questionnaire (IPAQ); MET min/week was calculated and quartiles constructed. Diabetes diagnosis was defined according to the ADA criteria. During 2011-2012, a 10-year follow-up was performed. RESULTS: n = 191 cases were recorded, yielding an incidence of 12.9%. In multivariable analysis, moderate physical activity level (331-1484 MET min/week) was found to decrease 10-year diabetes incidence by 53% compared to very low physical activity (< 150 MET min/week) (OR = 0.47; 95% CI 0.24, 0.93). For high physical activity level (> 1484 MET min/week), the results were not significant. The antidiabetic effect was found to be mediated by oxidized LDL and total antioxidant capacity. CONCLUSIONS: The current work revealed the significant beneficial role of moderate physical activity against diabetes development, potentially through attenuating oxidative stress.
OBJECTIVES: To evaluate the effect of physical activity levels on 10-year diabetes incidence and investigate the potential mechanism. METHODS: In 2001-2002, a random sample of apparently healthy 3042 men and women (18-89 years) was selected to participate in the ATTICA study. Several socio-demographic, clinical and lifestyle characteristics were recorded. Physical activity level was recorded through a translated, validated, version of International Physical Activity Questionnaire (IPAQ); MET min/week was calculated and quartiles constructed. Diabetes diagnosis was defined according to the ADA criteria. During 2011-2012, a 10-year follow-up was performed. RESULTS: n = 191 cases were recorded, yielding an incidence of 12.9%. In multivariable analysis, moderate physical activity level (331-1484 MET min/week) was found to decrease 10-year diabetes incidence by 53% compared to very low physical activity (< 150 MET min/week) (OR = 0.47; 95% CI 0.24, 0.93). For high physical activity level (> 1484 MET min/week), the results were not significant. The antidiabetic effect was found to be mediated by oxidized LDL and total antioxidant capacity. CONCLUSIONS: The current work revealed the significant beneficial role of moderate physical activity against diabetes development, potentially through attenuating oxidative stress.
Authors: F B Hu; R J Sigal; J W Rich-Edwards; G A Colditz; C G Solomon; W C Willett; F E Speizer; J E Manson Journal: JAMA Date: 1999-10-20 Impact factor: 56.272
Authors: Carlos A Celis-Morales; Francisco Perez-Bravo; Luis Ibañez; Carlos Salas; Mark E S Bailey; Jason M R Gill Journal: PLoS One Date: 2012-05-09 Impact factor: 3.240
Authors: Hmwe H Kyu; Victoria F Bachman; Lily T Alexander; John Everett Mumford; Ashkan Afshin; Kara Estep; J Lennert Veerman; Kristen Delwiche; Marissa L Iannarone; Madeline L Moyer; Kelly Cercy; Theo Vos; Christopher J L Murray; Mohammad H Forouzanfar Journal: BMJ Date: 2016-08-09
Authors: Laura Cloostermans; Wanda Wendel-Vos; Gerda Doornbos; Bethany Howard; Cora Lynn Craig; Mika Kivimäki; Adam G Tabak; Barbara J Jefferis; Kimmo Ronkainen; Wendy J Brown; Susan H S J Picavet; Yoav Ben-Shlomo; Jari Antero Laukkanen; Jussi Kauhanen; Wanda J E Bemelmans Journal: Int J Behav Nutr Phys Act Date: 2015-12-01 Impact factor: 6.457