Ting Martin Ma1, Jimm Grimm1, Riley McIntyre1, Heather Anderson-Keightly1, Lawrence R Kleinberg1, Russell K Hales1, Joseph Moore1, Tracy Vannorsdall2, Kristin J Redmond3. 1. Department of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University, Baltimore, MD, United States. 2. Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University, Baltimore, MD, United States; Department of Neurology, The Johns Hopkins University, Baltimore, MD, United States. 3. Department of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University, Baltimore, MD, United States. Electronic address: kjanson3@jhmi.edu.
Abstract
BACKGROUND AND PURPOSE: To prospectively evaluate hippocampal radiation dose volume effects and memory decline following cranial irradiation. MATERIAL AND METHODS: Effects of hippocampal radiation over a wide range of doses were investigated by combining data from three prospective studies. In one, adults with small cell lung cancer received hippocampal-avoidance prophylactic cranial irradiation. In the other two, adults with glioblastoma multiforme received neural progenitor cell sparing radiation or no sparing with extra dose delivered to subventricular zone. Memory was measured by the Hopkins Verbal Learning Test-Revised Delayed Recall (HVLT-R DR) at 6 months after radiation. Dose-volume histograms were generated and dose-response data were fitted to a nonlinear model. RESULTS: Of 60 patients enrolled, 30 were analyzable based on HVLT-R DR testing completion status, baseline HVLT-R DR and intracranial metastasis/recurrence or prior hippocampal resection status. We observed a dose-response of radiation to the hippocampus with regard to decline in HVLT-R DR. D50% of the bilateral hippocampi of 22.1 Gy is associated with 20% risk of decline. CONCLUSIONS: This prospective study demonstrates an association between hippocampal dose volume effects and memory decline measured by HVLT-R DR over a wide dose range. These data support a potential benefit of hippocampal sparing and encourage continued trial enrollment.
BACKGROUND AND PURPOSE: To prospectively evaluate hippocampal radiation dose volume effects and memory decline following cranial irradiation. MATERIAL AND METHODS: Effects of hippocampal radiation over a wide range of doses were investigated by combining data from three prospective studies. In one, adults with small cell lung cancer received hippocampal-avoidance prophylactic cranial irradiation. In the other two, adults with glioblastoma multiforme received neural progenitor cell sparing radiation or no sparing with extra dose delivered to subventricular zone. Memory was measured by the Hopkins Verbal Learning Test-Revised Delayed Recall (HVLT-R DR) at 6 months after radiation. Dose-volume histograms were generated and dose-response data were fitted to a nonlinear model. RESULTS: Of 60 patients enrolled, 30 were analyzable based on HVLT-R DR testing completion status, baseline HVLT-R DR and intracranial metastasis/recurrence or prior hippocampal resection status. We observed a dose-response of radiation to the hippocampus with regard to decline in HVLT-R DR. D50% of the bilateral hippocampi of 22.1 Gy is associated with 20% risk of decline. CONCLUSIONS: This prospective study demonstrates an association between hippocampal dose volume effects and memory decline measured by HVLT-R DR over a wide dose range. These data support a potential benefit of hippocampal sparing and encourage continued trial enrollment.
Authors: R Mohan; G S Mageras; B Baldwin; L J Brewster; G J Kutcher; S Leibel; C M Burman; C C Ling; Z Fuks Journal: Med Phys Date: 1992 Jul-Aug Impact factor: 4.071
Authors: Martin J B Taphoorn; Roger Stupp; Corneel Coens; David Osoba; Rolf Kortmann; Martin J van den Bent; Warren Mason; René O Mirimanoff; Brigitta G Baumert; Elizabeth Eisenhauer; Peter Forsyth; Andrew Bottomley Journal: Lancet Oncol Date: 2005-12 Impact factor: 41.316
Authors: David J Schretlen; Jessica M Winicki; Stephen M Meyer; S Marc Testa; Godfrey D Pearlson; Barry Gordon Journal: Clin Neuropsychol Date: 2009-08 Impact factor: 3.535
Authors: Kristin J Redmond; Russell K Hales; Heather Anderson-Keightly; Xian C Zhou; Megan Kummerlowe; Haris I Sair; Mario Duhon; Lawrence Kleinberg; Gary L Rosner; Tracy Vannorsdall Journal: Int J Radiat Oncol Biol Phys Date: 2017-03-14 Impact factor: 7.038
Authors: N Patrik Brodin; Per Munck af Rosenschöld; Malin Blomstrand; Anne Kiil-Berthlesen; Christian Hollensen; Ivan R Vogelius; Birgitta Lannering; Søren M Bentzen; Thomas Björk-Eriksson Journal: Neuro Oncol Date: 2013-12-09 Impact factor: 12.300
Authors: Jimm Grimm; Arjun Sahgal; Scott G Soltys; Gary Luxton; Ashish Patel; Scott Herbert; Jinyu Xue; Lijun Ma; Ellen Yorke; John R Adler; Iris C Gibbs Journal: Semin Radiat Oncol Date: 2016-01-04 Impact factor: 5.934
Authors: Kathryn R Tringale; Tanya T Nguyen; Roshan Karunamuni; Tyler Seibert; Minh-Phuong Huynh-Le; Michael Connor; Vitali Moiseenko; Mary Kay Gorman; Anisa Marshall; Michelle Devereux Tibbs; Nikdokht Farid; Daniel Simpson; Parag Sanghvi; Carrie R McDonald; Jona A Hattangadi-Gluth Journal: Int J Radiat Oncol Biol Phys Date: 2019-08-10 Impact factor: 7.038
Authors: Chengcheng Gui; Tracy D Vannorsdall; Lawrence R Kleinberg; Ryan Assadi; Joseph A Moore; Chen Hu; Alfredo Quiñones-Hinojosa; Kristin J Redmond Journal: Neurosurgery Date: 2020-07-01 Impact factor: 4.654
Authors: J Jacob; L Feuvret; J-M Simon; M Ribeiro; L Nichelli; C Jenny; D Ricard; D Psimaras; K Hoang-Xuan; P Maingon Journal: Neurol Sci Date: 2022-02-11 Impact factor: 3.307
Authors: Derek S Tsang; Laurence Kim; Zhihui Amy Liu; Laura Janzen; Mohammad Khandwala; Eric Bouffet; Normand Laperriere; Hitesh Dama; Dana Keilty; Tim Craig; Vijay Ramaswamy; David C Hodgson; Donald Mabbott Journal: Neuro Oncol Date: 2021-03-25 Impact factor: 12.300
Authors: Tomas Kazda; Adela Misove; Petr Burkon; Petr Pospisil; Ludmila Hynkova; Iveta Selingerova; Adam Dziacky; Renata Belanova; Martin Bulik; Zdenek Rehak; Alexandr Poprach; Ondrej Slama; Pavel Slampa; Ondrej Slaby; Radim Jancalek; Radek Lakomy Journal: Biomed Res Int Date: 2018-12-13 Impact factor: 3.411