Literature DB >> 29126141

Gastric Carcinomas With Lymphoid Stroma: Categorization and Comparison With Solid-Type Colonic Carcinomas.

Raul S Gonzalez1, Justin M M Cates2, Frank Revetta2, Loralee A McMahon1, Kay Washington2.   

Abstract

OBJECTIVES: To determine whether histologic features could help identify gastric carcinomas with lymphoid stroma associated with microsatellite instability (MSI) (ie, "medullary carcinomas"), Epstein-Barr virus (EBV) infection (termed lymphoepithelioma-like carcinomas in other organ systems), or neither.
METHODS: We identified 17 solid-type gastric carcinomas with lymphoid stroma, assessed EBV and MSI status, and compared features across groups. We also compared them with 51 solid-type colorectal adenocarcinomas.
RESULTS: In the stomach, EBV-associated carcinomas (n = 8) contained intratumoral germinal centers (P = .024) and eosinophils (P = .030) and lacked necrosis (P = .019) compared with MSI-associated carcinomas (n = 5) and non-EBV, non-MSI carcinomas (n = 4). In the colon, MSI-driven carcinomas (n = 40) more frequently contained intratumoral lymphocytes (P = .017) and neutrophils (P = .0050) and less often metastasized to distant sites (P = .0040) than poorly differentiated carcinomas lacking MSI (n = 11).
CONCLUSIONS: Morphology may help classify gastric carcinomas with lymphoid stroma, although ancillary testing appears more reliable. Lymphoepithelioma-like carcinoma and medullary carcinoma should not be used interchangeably. © American Society for Clinical Pathology, 2017. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

Entities:  

Keywords:  Epstein-Barr virus; Lymphoepithelioma-like carcinoma; Medullary carcinoma; Microsatellite instability; Stomach

Mesh：

Year:  2017        PMID： 29126141      PMCID： PMC6543885          DOI： 10.1093/ajcp/aqx096

Source DB:  PubMed          Journal:  Am J Clin Pathol        ISSN： 0002-9173            Impact factor:   2.493


  38 in total

1.  Loss of CDX2 expression and microsatellite instability are prominent features of large cell minimally differentiated carcinomas of the colon.

Authors:  T Hinoi; M Tani; P C Lucas; K Caca; R L Dunn; E Macri; M Loda; H D Appelman; K R Cho; E R Fearon
Journal:  Am J Pathol       Date:  2001-12       Impact factor: 4.307

Review 2.  Relationship between Epstein-Barr virus and lymphoepithelioma-like carcinoma of the lung: a clinicopathologic study of 6 cases and review of the literature.

Authors:  C Y Castro; M L Ostrowski; R Barrios; L K Green; H H Popper; S Powell; P T Cagle; J Y Ro
Journal:  Hum Pathol       Date:  2001-08       Impact factor: 3.466

3.  Gastric medullary carcinoma, a distinct entity associated with microsatellite instability-H, prominent intraepithelial lymphocytes and improved prognosis.

Authors:  B-J Lü; M Lai; L Cheng; J-Y Xu; Q Huang
Journal:  Histopathology       Date:  2004-11       Impact factor: 5.087

4.  Medullary adenocarcinoma of the colon: clinicopathologic study of 11 cases.

Authors:  J Jessurun; M Romero-Guadarrama; J C Manivel
Journal:  Hum Pathol       Date:  1999-07       Impact factor: 3.466

5.  Lymphoepithelioma-like carcinoma of the stomach: a subset of gastric carcinoma with distinct clinicopathological features and high prevalence of Epstein-Barr virus infection.

Authors:  H H Wang; M S Wu; C T Shun; H P Wang; C C Lin; J T Lin
Journal:  Hepatogastroenterology       Date:  1999 Mar-Apr

6.  The comparison of the prognosis between Epstein-Barr virus (EBV)-positive gastric carcinomas and EBV-negative ones.

Authors:  Yuko Kijima; Sumiya Ishigami; Shuichi Hokita; Chihaya Koriyama; Suminori Akiba; Yoshito Eizuru; Takashi Aikou
Journal:  Cancer Lett       Date:  2003-10-08       Impact factor: 8.679

7.  Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer.

Authors:  Christine M Ribic; Daniel J Sargent; Malcolm J Moore; Stephen N Thibodeau; Amy J French; Richard M Goldberg; Stanley R Hamilton; Pierre Laurent-Puig; Robert Gryfe; Lois E Shepherd; Dongsheng Tu; Mark Redston; Steven Gallinger
Journal:  N Engl J Med       Date:  2003-07-17       Impact factor: 91.245

8.  Lymphocyte-rich gastric cancer: associations with Epstein-Barr virus, microsatellite instability, histology, and survival.

Authors:  Karen L Grogg; Christine M Lohse; V Shane Pankratz; Kevin C Halling; Thomas C Smyrk
Journal:  Mod Pathol       Date:  2003-07       Impact factor: 7.842

9.  Treatment of nasopharyngeal carcinoma with Epstein-Barr virus--specific T lymphocytes.

Authors:  Karin C M Straathof; Catherine M Bollard; Uday Popat; M Helen Huls; Teresita Lopez; M Craig Morriss; Mary V Gresik; Adrian P Gee; Heidi V Russell; Malcolm K Brenner; Cliona M Rooney; Helen E Heslop
Journal:  Blood       Date:  2004-11-12       Impact factor: 22.113

10.  Microsatellite instability, Epstein-Barr virus, mutation of type II transforming growth factor beta receptor and BAX in gastric carcinomas in Hong Kong Chinese.

Authors:  S Y Leung; S T Yuen; L P Chung; K M Chu; M P Wong; F J Branicki; J C Ho
Journal:  Br J Cancer       Date:  1999-02       Impact factor: 7.640
View more
  4 in total

Review 1.  Thirty years of Epstein-Barr virus-associated gastric carcinoma.

Authors:  Masashi Fukayama; Hiroyuki Abe; Akiko Kunita; Aya Shinozaki-Ushiku; Keisuke Matsusaka; Tetsuo Ushiku; Atsushi Kaneda
Journal:  Virchows Arch       Date:  2019-12-13       Impact factor: 4.064

2.  A case of poorly differentiated adenocarcinoma with lymphoid stroma originated in the ascending colon diagnosed as lymphoepithelioma-like carcinoma.

Authors:  Kengo Kai; Hideki Hidaka; Takeshi Nakamura; Yuji Ueda; Kosuke Marutsuka; Takuto Ikeda; Atsushi Nanashima
Journal:  Clin J Gastroenterol       Date:  2019-12-16

3.  Solid-type poorly differentiated adenocarcinoma of the stomach: Deficiency of mismatch repair and SWI/SNF complex.

Authors:  Shinichi Tsuruta; Kenichi Kohashi; Yuichi Yamada; Minako Fujiwara; Yutaka Koga; Eikichi Ihara; Yoshihiro Ogawa; Eiji Oki; Masafumi Nakamura; Yoshinao Oda
Journal:  Cancer Sci       Date:  2020-01-28       Impact factor: 6.716

4.  Clinicopathological Features and Prognostic Implication of Gastric Carcinoma with Lymphoid Stroma.

Authors:  Jung-Soo Pyo; Nae Yu Kim; Byoung Kwan Son; Hyo Young Lee; Il Hwan Oh; Kwang Hyun Chung
Journal:  Gastroenterol Res Pract       Date:  2020-12-03       Impact factor: 2.260
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.