BACKGROUND: The Free and Cued Selective Reminding Test (FCSRT) is the most accurate test for the diagnosis of prodromal Alzheimer's disease (AD). Recently, a novel cognitive test, the Loewenstein-Acevedo Scale for Semantic Interference and Learning (LASSI-L), has been developed in order to provide an early diagnosis. OBJECTIVE: To compare the diagnostic accuracy of the FCSRT and the LASSI-L for the diagnosis of AD in its preclinical and prodromal stages using 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) as a reference. METHODS: Fifty patients consulting for subjective memory complaints without functional impairment and at risk for AD were enrolled and evaluated using FCSRT, LASSI-L, and FDG-PET. Participants were evaluated using a comprehensive neurological and neuropsychological protocol and were assessed with the FCSRT and LASSI-L. FDG-PET was acquired concomitantly and used for classification of patients as AD or non-AD according to brain metabolism using both visual and semi-quantitative methods. RESULTS: LASSI-L scores allowed a better classification of patients as AD/non-AD in comparison to FCSRT. Logistic regression analysis showed delayed recall and failure to recovery from proactive semantic interference from LASSI-L as independent statistically significant predictors, obtaining an area under the curve of 0.894. This area under the curve provided a better discrimination than the best FCSRT score (total delayed recall, area under the curve 0.708, p = 0.029). CONCLUSIONS: The LASSI-L, a cognitive stress test, was superior to FCSRT in the prediction of AD features on FDG-PET. This emphasizes the possibility to advance toward an earlier diagnosis of AD from a clinical perspective.
BACKGROUND: The Free and Cued Selective Reminding Test (FCSRT) is the most accurate test for the diagnosis of prodromal Alzheimer's disease (AD). Recently, a novel cognitive test, the Loewenstein-Acevedo Scale for Semantic Interference and Learning (LASSI-L), has been developed in order to provide an early diagnosis. OBJECTIVE: To compare the diagnostic accuracy of the FCSRT and the LASSI-L for the diagnosis of AD in its preclinical and prodromal stages using 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) as a reference. METHODS: Fifty patients consulting for subjective memory complaints without functional impairment and at risk for AD were enrolled and evaluated using FCSRT, LASSI-L, and FDG-PET. Participants were evaluated using a comprehensive neurological and neuropsychological protocol and were assessed with the FCSRT and LASSI-L. FDG-PET was acquired concomitantly and used for classification of patients as AD or non-AD according to brain metabolism using both visual and semi-quantitative methods. RESULTS: LASSI-L scores allowed a better classification of patients as AD/non-AD in comparison to FCSRT. Logistic regression analysis showed delayed recall and failure to recovery from proactive semantic interference from LASSI-L as independent statistically significant predictors, obtaining an area under the curve of 0.894. This area under the curve provided a better discrimination than the best FCSRT score (total delayed recall, area under the curve 0.708, p = 0.029). CONCLUSIONS: The LASSI-L, a cognitive stress test, was superior to FCSRT in the prediction of AD features on FDG-PET. This emphasizes the possibility to advance toward an earlier diagnosis of AD from a clinical perspective.
Authors: Marcela Kitaigorodsky; Rosie E Curiel Cid; Elizabeth Crocco; Katherine L Gorman; Christian J González-Jiménez; Maria Greig-Custo; Warren W Barker; Ranjan Duara; David A Loewenstein Journal: J Psychiatr Res Date: 2021-08-26 Impact factor: 4.791
Authors: David A Loewenstein; Rosie E Curiel; Steven DeKosky; Russell M Bauer; Monica Rosselli; Salvador M Guinjoan; Malek Adjouadi; Ailyn Peñate; William W Barker; Sindy Goenaga; Todd Golde; Maria T Greig-Custo; Kevin S Hanson; Chunfei Li; Gabriel Lizarraga; Michael Marsiske; Ranjan Duara Journal: Neurology Date: 2018-08-03 Impact factor: 9.910
Authors: Edmarie Guzmán-Vélez; Sehily Jaimes; Daniel C Aguirre-Acevedo; Daniel J Norton; Kathryn V Papp; Rebecca Amariglio; Dorene Rentz; Ana Baena; Eliana Henao; Victoria Tirado; Claudia Muñoz; Margarita Giraldo; Reisa A Sperling; Francisco Lopera; Yakeel T Quiroz Journal: J Alzheimers Dis Date: 2018 Impact factor: 4.472
Authors: Rosie E Curiel Cid; David A Loewenstein; Monica Rosselli; Jordi A Matias-Guiu; Daema Piña; Malek Adjouadi; Mercedes Cabrerizo; Russell M Bauer; Aldrich Chan; Steven T DeKosky; Todd Golde; Maria T Greig-Custo; Gabriel Lizarraga; Ailyn Peñate; Ranjan Duara Journal: Alzheimers Dement (Amst) Date: 2019-08-02
Authors: Jordi A Matias-Guiu; Ana Cortés-Martínez; Rosie E Curiel; Alfonso Delgado-Álvarez; Aníbal Fernández-Oliveira; Vanesa Pytel; Paloma Montero; Teresa Moreno-Ramos; David A Loewenstein; Jorge Matías-Guiu Journal: Front Neurol Date: 2020-04-21 Impact factor: 4.086