Kibeom Park1, Nam Hyun Cho2,3, Mansik Jeon1, Sang Heun Lee4, Jeong Hun Jang5, Stephen A Boppart6,7, Woonggyu Jung8, Jeehyun Kim1. 1. a School of Electronics Engineering, College of IT Engineering , Kyungpook National University , Daegu , Korea. 2. b Eaton-Peabody Laboratories , Massachusetts Eye and Ear Infirmary (MEEI) , Boston , MA , USA. 3. c Department of Otology and Laryngology , Harvard Medical School , Boston , MA , USA. 4. d Department of Otorhinolaryngology , Daegu Veterans Hospital , Daegu , Korea. 5. e Department of Otorhinolaryngology , College of Medicine, Ajou University , Suwon , Korea. 6. f Department of Electrical and Computer Engineering , University of Illinois at Urbana-Champaign , Urbana , IL , USA. 7. g Beckman Institute for Advanced Science , Urbana , IL , USA. 8. h School of Nano-Bioscience and Chemical Engineering, School of Electrical and Computer Engineering , Ulsan National Institute of Science and Technology , Ulsan , Korea.
Abstract
OBJECTIVE: Conventional otoscopes and oto-endoscopes, which are used to examine the tympanic membrane (TM), do not provide tomographic information. Optical coherence tomography (OCT) non-invasively reveals the depth-resolved internal microstructure of the TM with very high spatial resolution. We designed this study to examine the TMs with middle ear diseases using a handheld otoscope employing 860 nm spectral domain (SD)-OCT, combined with video camera and to demonstrate the clinical applicability of this system. DESIGN: A total of 120 patients with otologic symptoms were enrolled. TM images were obtained using the handheld OCT-based otoscope (860 nm central wave length, 15 μm axial resolution, 15 μm lateral resolution, and 7 mm scanning range using relay lens). Both OCT and oto-endoscope images were compared according to the clinical characteristics such as perforation, retraction, and postoperative healing process. RESULTS: The objective grade about the thickness of perforation margins and the accurate information about the extent of TM retraction that was not distinguishable by oto-endoscopic exam could be identified using this system. The postoperative healing process of TMs could be also followed using the OCT device. CONCLUSION: These analyses from the surgeon-oriented perspective suggest another useful application of the handheld OCT device.
OBJECTIVE: Conventional otoscopes and oto-endoscopes, which are used to examine the tympanic membrane (TM), do not provide tomographic information. Optical coherence tomography (OCT) non-invasively reveals the depth-resolved internal microstructure of the TM with very high spatial resolution. We designed this study to examine the TMs with middle ear diseases using a handheld otoscope employing 860 nm spectral domain (SD)-OCT, combined with video camera and to demonstrate the clinical applicability of this system. DESIGN: A total of 120 patients with otologic symptoms were enrolled. TM images were obtained using the handheld OCT-based otoscope (860 nm central wave length, 15 μm axial resolution, 15 μm lateral resolution, and 7 mm scanning range using relay lens). Both OCT and oto-endoscope images were compared according to the clinical characteristics such as perforation, retraction, and postoperative healing process. RESULTS: The objective grade about the thickness of perforation margins and the accurate information about the extent of TM retraction that was not distinguishable by oto-endoscopic exam could be identified using this system. The postoperative healing process of TMs could be also followed using the OCT device. CONCLUSION: These analyses from the surgeon-oriented perspective suggest another useful application of the handheld OCT device.
Authors: Guillermo L Monroy; Ryan L Shelton; Ryan M Nolan; Cac T Nguyen; Michael A Novak; Malcolm C Hill; Daniel T McCormick; Stephen A Boppart Journal: Laryngoscope Date: 2015-01-19 Impact factor: 3.325
Authors: Hamid R Djalilian; James Ridgway; Majestic Tam; Ali Sepehr; Zhongping Chen; Brian J F Wong Journal: Otol Neurotol Date: 2008-12 Impact factor: 2.311
Authors: Simon S Gao; Anping Xia; Tao Yuan; Patrick D Raphael; Ryan L Shelton; Brian E Applegate; John S Oghalai Journal: Opt Express Date: 2011-08-01 Impact factor: 3.894
Authors: Cac T Nguyen; Haohua Tu; Eric J Chaney; Charles N Stewart; Stephen A Boppart Journal: Biomed Opt Express Date: 2010-10-07 Impact factor: 3.732
Authors: Guillermo L Monroy; Jungeun Won; Jindou Shi; Malcolm C Hill; Ryan G Porter; Michael A Novak; Wenzhou Hong; Pawjai Khampang; Joseph E Kerschner; Darold R Spillman; Stephen A Boppart Journal: Biomed Opt Express Date: 2022-05-26 Impact factor: 3.562
Authors: Diego Preciado; Ryan M Nolan; Radhika Joshi; Gina M Krakovsky; Anqi Zhang; Nickolas A Pudik; Nankee K Kumar; Ryan L Shelton; Stephen A Boppart; Nancy M Bauman Journal: Otolaryngol Head Neck Surg Date: 2020-01-21 Impact factor: 3.497