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Literature DB >> 291240

Properdin factor B-polymorphism. An indication for the existence of a Bf O-allele.

Abstract

The polymorphism of the properdin factor B (Bf, C3-proactivator, GBG = glycin-rich-beta-glycoprotein) has been investigated by high voltage agarose gel immunofixation electrophoresis in 1115 unrelated persons from Southern Germany. Seven phenotypes were observed; the allele frequencies were calculated as BfS = 0.8094, BfF = 0.1790, BfSI = 0.0094, BfFI = 0.0022. A study of 94 parents with 98 children and 420 mother-child combinations showed no deviation from the assumed autosomal codominant mode of inheritance. In one additional family the findings suggested the existence of a silent allele at the Bf-locus.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 1979 PMID： 291240 DOI： 10.1007/bf02333329

Source DB: PubMed Journal: Z Rechtsmed ISSN： 0044-3433

17 in total

1. Properdin factor B (glycine-rich beta-glycoprotein or C3 proactivator)-polymorphism: genetic and biochemical aspects. First application to paternity cases.

Authors: G Mauff; K Hummel; G Pulverer
Journal: Z Immunitatsforsch Exp Klin Immunol Date: 1975-10

2. Polymorphism of properdin factor B in South African Negroid, Indian and Colored populations.

Authors: G Mauff; F D Gauchel; H W Hitzeroth
Journal: Hum Genet Date: 1976-08-30 Impact factor: 4.132

3. Bf polymorphism: another variant (S0.8).

Authors: G Hauptmann; E Wertheimer; M M Tongio; S Mayer
Journal: Hum Genet Date: 1977-04-07 Impact factor: 4.132

4. Linkage of HL-A and GBG.

Authors: F H Allen
Journal: Vox Sang Date: 1974 Impact factor: 2.144

5. Immunofixation electrophoresis: a technique for the study of protein polymorphism.

Authors: C A Alper; A M Johnson
Journal: Vox Sang Date: 1969-11 Impact factor: 2.144

6. Properdin factor B (Bf) polymorphism in Norway.

Authors: P Teisberg; B Olaisen
Journal: Vox Sang Date: 1977 Impact factor: 2.144

7. Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies.

Authors: C B Laurell
Journal: Anal Biochem Date: 1966-04 Impact factor: 3.365

8. Linkage group HL-A-MLC-BF (properdin factor B). The site of the Bf locus at the immunogenetic linkage group on chromosome 6.

Authors: C Rittner; H Grosse-Wilde; B Netzel; S Scholz; H Lorenz; E D Albert
Journal: Humangenetik Date: 1975

9. Properdin factor b-polymorphism in the population of Hessen, Germany.

Authors: P Kühnl; W Spielmann
Journal: Z Rechtsmed Date: 1978-05-29

10. Haplotype analysis of the linkage group HLA-A:HAL-B:Bf and its bearing on the interpretation of the linkage disequilibrium.

Authors: K Bender; A Mayerová; R Frank; C Hiller; T Wienker
Journal: Hum Genet Date: 1977-04-15 Impact factor: 4.132

9 in total

1. Apparently non-expressed alleles of factor B (BF) code for hypomorphic proteins.

Authors: I Siemens; M Brenden; G Mauff; M Abbal; E Du Toit; J Bertrams; G Geserick
Journal: Immunogenetics Date: 1992 Impact factor: 2.846

2. Allelic differences in hemolytic activity and protein concentration of BF molecules are found in association with particular HLA haplotypes.

Authors: M L Lokki; S A Koskimies
Journal: Immunogenetics Date: 1991 Impact factor: 2.846

Properdin factor B-polymorphism. An indication for the existence of a Bf O-allele.

1. Properdin factor B (glycine-rich beta-glycoprotein or C3 proactivator)-polymorphism: genetic and biochemical aspects. First application to paternity cases.

2. Polymorphism of properdin factor B in South African Negroid, Indian and Colored populations.

3. Bf polymorphism: another variant (S0.8).

4. Linkage of HL-A and GBG.

5. Immunofixation electrophoresis: a technique for the study of protein polymorphism.

6. Properdin factor B (Bf) polymorphism in Norway.

7. Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies.

8. Linkage group HL-A-MLC-BF (properdin factor B). The site of the Bf locus at the immunogenetic linkage group on chromosome 6.

9. Properdin factor b-polymorphism in the population of Hessen, Germany.

10. Haplotype analysis of the linkage group HLA-A:HAL-B:Bf and its bearing on the interpretation of the linkage disequilibrium.

1. Apparently non-expressed alleles of factor B (BF) code for hypomorphic proteins.

2. Allelic differences in hemolytic activity and protein concentration of BF molecules are found in association with particular HLA haplotypes.

3. Properdin factor B(Bf) polymorphism in the population of Veneto, Italy.

4. A new BF variant (BF S11) with information for orientation of MHC class III genes.

5. Another family with a silent allele of properdin factor B polymorphism (BF QO).

Review 6. On the significance of C2, C4, and factor B polymorphisms in disease.

7. Five new rare variants of the properdin factor B (BF) locus.

8. Further study on a BF silent allele.

9. Two new Bf S subtypes revealed by isoelectric focusing and immunofixation.