V Pampanini1, E Inzaghi2, D Germani3, A Alterio4, A Puglianiello3, A Alisi4, V Nobili4, S Cianfarani5. 1. Department of Women's and Children's Health, Pediatric Endocrinology Unit, Karolinska Institutet and University Hospital, 17176, Stockholm, Sweden. Electronic address: valentina.pampanini@ki.se. 2. Dipartimento Pediatrico Universitario Ospedaliero "Bambino Gesù" Children's Hospital - Tor Vergata University, 00165, Rome, Italy. 3. Department of Systems Medicine, Tor Vergata University, 00173, Rome, Italy. 4. Hepato-Metabolic Disease Unit, "Bambino Gesù" Children's Hospital - IRCCS, Rome, Italy. 5. Department of Women's and Children's Health, Pediatric Endocrinology Unit, Karolinska Institutet and University Hospital, 17176, Stockholm, Sweden; Dipartimento Pediatrico Universitario Ospedaliero "Bambino Gesù" Children's Hospital - Tor Vergata University, 00165, Rome, Italy.
Abstract
BACKGROUND AND AIMS: Fetuin-A has been proposed as a marker of liver damage in adults with obesity-related NAFLD. The aim of this study was to test serum fetuin-A concentrations in obese children with NAFLD diagnosed either by ultrasonography or by liver biopsy and to determine its applicability as predictive tool in pediatric NAFLD. METHODS AND RESULTS: Metabolic parameters and fetuin-A levels were investigated in 81 obese children with NAFLD diagnosed by biopsy, 79 obese children with NAFLD defined by liver ultrasonography and 23 lean subjects. Serum fetuin-A correlated significantly with age, waist circumference, systolic blood pressure, fasting insulin and 2-h postload insulin during OGTT, HOMA-IR, ISI, CRP, and apo B levels. Obese children with NAFLD detected by ultrasonography had significantly higher fetuin-A levels compared to those with normal liver. In obese children who underwent liver biopsy, no significant differences were detected in fetuin-A levels between subject with nonalcoholic steatohepatitis and those with simple steatosis. Fetuin-A was not different between obese and lean children. CONCLUSION: Fetuin-A is not related with the degree of liver damage in obese children with NAFLD and its routine measurement as marker of liver disease severity is therefore not recommended.
BACKGROUND AND AIMS: Fetuin-A has been proposed as a marker of liver damage in adults with obesity-related NAFLD. The aim of this study was to test serum fetuin-A concentrations in obesechildren with NAFLD diagnosed either by ultrasonography or by liver biopsy and to determine its applicability as predictive tool in pediatric NAFLD. METHODS AND RESULTS: Metabolic parameters and fetuin-A levels were investigated in 81 obesechildren with NAFLD diagnosed by biopsy, 79 obesechildren with NAFLD defined by liver ultrasonography and 23 lean subjects. Serum fetuin-A correlated significantly with age, waist circumference, systolic blood pressure, fasting insulin and 2-h postload insulin during OGTT, HOMA-IR, ISI, CRP, and apo B levels. Obesechildren with NAFLD detected by ultrasonography had significantly higher fetuin-A levels compared to those with normal liver. In obesechildren who underwent liver biopsy, no significant differences were detected in fetuin-A levels between subject with nonalcoholic steatohepatitis and those with simple steatosis. Fetuin-A was not different between obese and lean children. CONCLUSION:Fetuin-A is not related with the degree of liver damage in obesechildren with NAFLD and its routine measurement as marker of liver disease severity is therefore not recommended.
Authors: P Borsky; Z Fiala; C Andrys; M Beranek; K Hamakova; J Kremlacek; A Malkova; T Svadlakova; J Krejsek; V Palicka; V Rehacek; L Kotingova; L Borska Journal: Physiol Res Date: 2021-05-12 Impact factor: 1.881
Authors: Xiongfeng Pan; Atipatsa C Kaminga; Jihua Chen; Miyang Luo; Jiayou Luo Journal: Int J Environ Res Public Health Date: 2020-04-15 Impact factor: 3.390