Shu-Xu Du1, Yong-Rui Jia2, Si-Qi Ren3, Xiao-Jun Gong3, Hong Tang3, Wu Wan-Shui3, Sun Li-Ming3. 1. Department of Pediatrics, BeijingShijitan Hospital, Capital Medical University, Beijing, 100038, China. Electronic address: duhsuxu2011@sina.com. 2. Health Science Center, Peking University, Beijing, 100191, China. 3. Department of Pediatrics, BeijingShijitan Hospital, Capital Medical University, Beijing, 100038, China.
Abstract
PURPOSE: we studied the effect of Bacillus licheniformis preparation (ZCS) on CNST (central nervous system tumor) patients undergoing the gastrointestinal symptoms and inflammation induced by radiotherapy. MATERIALS AND METHODS: 160 CNST patients withcraniospinal irradiation (CSI) treatment were divided into experiment and control group. The experiment group patients took one capsule per time of ZCS and three times a day until the end of radiotherapy, starting one day before radiotherapy. While the patients in control group were administrated placebo without any probiotics. Serum from one day before radiotherapy and the first day after radiotherapy were collected to measure the ET, CRP, TNF-α, IL-1β and IL-6. RESULTS: More than 70% CNST pediatric patients suffered from different degrees of gastrointestinal symptoms after radiotherapy, including mouth ulcer, nausea, vomiting, abdominal pain and diarrhea. And there was an obviously increased of serum ET, TNF-α, IL-1β, IL-6 and CRP after RT. Importantly, a markedly decreased of ET, CRP and inflammatory cytokines were detected in the experiment group comparing to the control group after radiotherapy, as well as the relief of the gastrointestinal symptoms. However, improvement of probiotics (or ZCS) of the survival rate of CNST children and the recurrence of tumor are not observed in this study. CONCLUSIONS: Prophylactically administrated ZCS during radiotherapy for CNST patients can relieve RT-related gastrointestinal symptoms and inflammatory reaction.
RCT Entities:
PURPOSE: we studied the effect of Bacillus licheniformis preparation (ZCS) on CNST (central nervous system tumor) patients undergoing the gastrointestinal symptoms and inflammation induced by radiotherapy. MATERIALS AND METHODS: 160 CNST patients with craniospinal irradiation (CSI) treatment were divided into experiment and control group. The experiment group patients took one capsule per time of ZCS and three times a day until the end of radiotherapy, starting one day before radiotherapy. While the patients in control group were administrated placebo without any probiotics. Serum from one day before radiotherapy and the first day after radiotherapy were collected to measure the ET, CRP, TNF-α, IL-1β and IL-6. RESULTS: More than 70% CNST pediatric patients suffered from different degrees of gastrointestinal symptoms after radiotherapy, including mouth ulcer, nausea, vomiting, abdominal pain and diarrhea. And there was an obviously increased of serum ET, TNF-α, IL-1β, IL-6 and CRP after RT. Importantly, a markedly decreased of ET, CRP and inflammatory cytokines were detected in the experiment group comparing to the control group after radiotherapy, as well as the relief of the gastrointestinal symptoms. However, improvement of probiotics (or ZCS) of the survival rate of CNST children and the recurrence of tumor are not observed in this study. CONCLUSIONS: Prophylactically administrated ZCS during radiotherapy for CNST patients can relieve RT-related gastrointestinal symptoms and inflammatory reaction.
Authors: Aleksandra Garczyk; Iwona Kaliciak; Konstanty Drogowski; Paulina Horwat; Stanisław Kopeć; Zuzanna Staręga; Paweł Bogdański; Marta Stelmach-Mardas; Marcin Mardas Journal: J Clin Med Date: 2022-06-14 Impact factor: 4.964
Authors: Caroline Diorio; Paula D Robinson; Roland A Ammann; Elio Castagnola; Kelley Erickson; Adam Esbenshade; Brian T Fisher; Gabrielle M Haeusler; Susan Kuczynski; Thomas Lehrnbecher; Robert Phillips; Sandra Cabral; L Lee Dupuis; Lillian Sung Journal: J Clin Oncol Date: 2018-09-14 Impact factor: 44.544