| Literature DB >> 29120328 |
Jeremy A Miller1, Angela Guillozet-Bongaarts1, Laura E Gibbons2, Nadia Postupna3, Anne Renz4, Allison E Beller3, Susan M Sunkin1, Lydia Ng1, Shannon E Rose3, Kimberly A Smith1, Aaron Szafer1, Chris Barber1, Darren Bertagnolli1, Kristopher Bickley1, Krissy Brouner1, Shiella Caldejon1, Mike Chapin1, Mindy L Chua3, Natalie M Coleman3, Eiron Cudaback3, Christine Cuhaciyan1, Rachel A Dalley1, Nick Dee1, Tsega Desta1, Tim A Dolbeare1, Nadezhda I Dotson1, Michael Fisher1, Nathalie Gaudreault1, Garrett Gee1, Terri L Gilbert1, Jeff Goldy1, Fiona Griffin1, Caroline Habel1, Zeb Haradon1, Nika Hejazinia1, Leanne L Hellstern3, Steve Horvath5, Kim Howard3, Robert Howard1, Justin Johal1, Nikolas L Jorstad3, Samuel R Josephsen3, Chihchau L Kuan1, Florence Lai1, Eric Lee1, Felix Lee1, Tracy Lemon1, Xianwu Li3, Desiree A Marshall3, Jose Melchor1, Shubhabrata Mukherjee2, Julie Nyhus1, Julie Pendergraft1, Lydia Potekhina1, Elizabeth Y Rha3, Samantha Rice3, David Rosen1, Abharika Sapru3, Aimee Schantz3, Elaine Shen1, Emily Sherfield3, Shu Shi1, Andy J Sodt1, Nivretta Thatra1, Michael Tieu1, Angela M Wilson3, Thomas J Montine3, Eric B Larson4, Amy Bernard1, Paul K Crane2, Richard G Ellenbogen6, C Dirk Keene3, Ed Lein1.
Abstract
As more people live longer, age-related neurodegenerative diseases are an increasingly important societal health issue. Treatments targeting specific pathologies such as amyloid beta in Alzheimer's disease (AD) have not led to effective treatments, and there is increasing evidence of a disconnect between traditional pathology and cognitive abilities with advancing age, indicative of individual variation in resilience to pathology. Here, we generated a comprehensive neuropathological, molecular, and transcriptomic characterization of hippocampus and two regions cortex in 107 aged donors (median = 90) from the Adult Changes in Thought (ACT) study as a freely-available resource (http://aging.brain-map.org/). We confirm established associations between AD pathology and dementia, albeit with increased, presumably aging-related variability, and identify sets of co-expressed genes correlated with pathological tau and inflammation markers. Finally, we demonstrate a relationship between dementia and RNA quality, and find common gene signatures, highlighting the importance of properly controlling for RNA quality when studying dementia.Entities:
Keywords: Alzheimer's disease; aging; dementia; gene expression; human; neuroscience
Mesh：
Year: 2017 PMID： 29120328 PMCID： PMC5679757 DOI： 10.7554/eLife.31126
Source DB: PubMed Journal: Elife ISSN： 2050-084X Impact factor: 8.140